TY -的T1 -未来的扩散张量成像研究轻度创伤性脑损伤JF -神经学乔-神经病学SP - 643 LP - 650 - 10.1212 / WNL。首页0 b013e3181d0ccdd六世- 74 - 8 AU - a。r . Mayer AU - j .凌盟- m . v . Mannell AU - c .斯洛伐克总统加什帕罗维奇AU - j·p·菲利普斯AU - d Doezema AU - r . Reichard盟r·a·杨Y1 - 2010/02/23 UR - //www.ez-admanager.com/content/74首页/8/643.abstract N2 -目标:只有少数研究调查的性质、功能意义和白质的异常与轻度创伤性脑损伤(mTBI)在semi-acute阶段的损伤。本研究使用扩散张量成像(DTI)调查白质完整性和传统解剖扫描的准确性相比,神经心理测试和DTI的客观分类mTBI患者控制。方法:22患者semi-acute mTBI(平均= 12天postinjury), 21个匹配的健康对照组,和一个更大的样本健康对照组(n = 32)与广泛的成像进行了研究和临床的电池。参与者的一个子集是检查纵向3 - 5个月后首次访问。结果:mTBI患者没有临床成像扫描或神经心理学不同于控制性能,尽管尺度效应与文献值相符。相比之下,mTBI患者显示出了明显更大的分数各向异性的结果减少径向扩散系数在胼胝体和几个左半球大片。DTI措施比传统的临床措施更能精确地分类患者控制。纵向数据提供了初步的证据偏在几个白质束DTI值正常化。结论:当前白质异常的结果表明可能存在细胞毒性水肿在semi-acute阶段的轻度创伤性脑损伤(mTBI)。 Initial mechanical damage to axons disrupts ionic homeostasis and the ratio of intracellular and extracellular water, primarily affecting diffusion perpendicular to axons. Diffusion tensor imaging measurement may have utility for objectively classifying mTBI, and may serve as a potential biomarker of recovery. ADC=apparent diffusion coefficient; CC=corpus callosum; CCI=cortical impact injury model; CR=corona radiata; DTI=diffusion tensor imaging; EC=external capsule; FA=fractional anisotropy; FPI=fluid percussion injury model; HC=healthy controls; IC=internal capsule; JHU=Johns Hopkins University; MANCOVA=multivariate analysis of covariance; mTBI=mild traumatic brain injury; RD=radial diffusivity; ROI=region of interest; SCR=superior corona radiata; SLF=superior longitudinal fasciculus; UF=uncinate fasciculus. ER -