作者@article {Little558 = {D。m .小m·f·克劳斯和j·约瑟夫·e·k·吉里和t . Susmaras周x j . n . Pliskin和p . b . Gorelick} title ={丘脑的完整性是执行功能障碍在创伤性脑损伤},体积={74}={7},页面= {558 - 564}= {2010},doi = {10.1212 / WNL。出版商0 b013e3181cff5d5} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:量化的创伤性脑损伤对完整性的影响丘脑皮层的投射纤维和评估是否损害这些首页纤维在执行功能障碍占慢性创伤性脑损伤。方法:高分辨率(立体像素大小:0.78毫米0.78毫米{\ texttimes} {\ texttimes} 3 mm3)扩散张量磁共振成像的丘脑进行史的患者单身,24日closed-head创伤性脑损伤(TBI)(12轻度创伤性脑损伤和中度到重度创伤性脑损伤)和12岁,education-matched控制。详细的神经心理学测试重点是执行功能也进行了。分数各向异性从12个区域提取感兴趣的皮质和胼胝体结构和7感兴趣的皮质下区域(腹前,前腹侧,dorsomedial,腹后外侧,腹后内侧,和枕丘脑核)。结果:相对于控制,患者脑损伤的历史显示减少分数各向异性在前部和后部放射冠,钳,胼胝体的主体,从种子体素纤维识别前和前丘脑腹侧核。从cortico-cortico分数各向异性和胼胝体区域感兴趣的并不占重要的神经心理功能差异。然而,从丘脑部分各向异性种子体素占方差在执行功能,关注,和记忆。结论:这些数据提供初步证据表明,创伤性脑损伤和产生的脑弥漫性轴索损伤导致丘脑投射纤维损伤和临床意义的认知。 ACR=anterior corona radiata; AN=anterior thalamic nucleus; bCC=body of the corpus callosum; CST=cortical-spinal tract; DAI=diffuse axonal injury; DM=dorsomedial nucleus; DTI=diffusion tensor imaging; FA=fractional anisotropy; fMaj=forceps major; fMin=forceps minor; FOV=field of view; FSE=fast spin echo; gCC=genu of the corpus callosum; IC=internal capsule; IFOF=inferior frontal occipital fasciculus; LOC=loss of consciousness; miTBI=mild TBI; msTBI=moderate to severe TBI; NEX=number of excitations; PCR=posterior corona radiata; PTA=posttraumatic amnesia; PU=pulvinar; ROI=region of interest; sCC=splenium of the corpus callosum; SLF=superior longitudinal fasciculus; SS=sagittal stratum; TBI=traumatic brain injury; TE=echo time; TR=repetition time; VA=ventral anterior thalamic nucleus; VL=ventral lateral thalamic nucleus; VPL=ventral posterior lateral nucleus; VPM=ventral posterior medial nucleus.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/74/7/558}, eprint = {//www.ez-admanager.com/content/74/7/558.full.pdf}, journal = {Neurology} }