PT -期刊文章盟j . h . Jhoo AU - i - y。Yoon AU - y k金盟- s聪盟- j - m。金盟- s . b .李盟- t·h·金盟s h .月球非盟- s e·金盟k . w . Kim TI -可用性的大脑5 -羟色胺转运蛋白的不宁腿综合症患者援助- 10.1212 / WNL。0 b013e3181cef824 DP - 2010 2月09年TA -神经首页病学第六PG - 513 - 518 - 74 IP - 6 4099 - //www.ez-admanager.com/content/74/6/513.short 4100 - //www.ez-admanager.com/content/74/6/513.full所以Neurology2010 09年2月;74 AB -背景:选择性5 -羟色胺再摄取抑制剂与不宁腿综合症的风险相关(RLS),这表明羟色胺神经传递可能引发或加剧RLS的失调。方法:我们比较的可用性羟色胺转运体(泽特)16 drug-naive RLS患者和健康对照组之间。泽特测量在脑桥和髓质通过[123 i] 2β-carbomethoxy-3β- (4-iodophenyl)托烷SPECT(β-CIT)。比特定的非特异性脑摄取(V3”)是用于所有的比较。RLS被诊断出据国立卫生研究所提出的标准,及其严重程度是衡量使用国际RLS研究组织(IRLSSG)严重程度的规模。结果:泽特的可用性是类似RLS组和对照组与脑桥(1.24±0.31 vs 1.24±0.25, p比; 0.1) and the medulla (0.99 ± 0.25 vs 1.00 ± 0.23, p > 0.1). However, IRLSSG Severity Scale scores increased with decrease of SERT availability in both the pons (β = −0.50, t = −3.19, p = 0.009) and the medulla (β = −0.42, t = −2.44, p = 0.03). Conclusions: Although serotonin transporter (SERT) availability in pons and medulla was similar in the restless legs syndrome (RLS) group and the control group, the severity of RLS symptoms increased as the availability of SERT decreased. These data partially support the hypothesis that an increase of serotonergic neurotransmission in the brainstem may exacerbate RLS, possibly via dual modulations on striatal dopaminergic neurotransmission and on the activities of spinal motor and sensory neurons. CERAD=Consortium to Establish a Registry for Alzheimer's Disease; DSM-IV=Diagnostic and Statistical Manual of Mental Disorders, 4th edition; GDS=Geriatric Depression Scale; IRLSSG=International RLS Study Group; MINI=Mini International Neuropsychiatric Interview; RLS=restless legs syndrome; ROI=region of interest; SERT=serotonin transporter; SNRI=serotonin-norepinephrine reuptake inhibitor; SSRI=selective serotonin reuptake inhibitor.