TY -的T1 -扩散低级间胶质瘤超越MRI-defined异常JF -神经学乔-神经病学SP - 1724 LP - 1731 - 10.1212 / WNL。首页0 b013e3181e04264六世- 74 - 21 AU - j . Pallud AU - p .无赖AU - b Devaux AU - s格哈盟- m . Badoual AU - c Deroulers AU - p .页面盟大肠Dezamis AU - c . Daumas-Duport盟F.-X。Roux Y1 - 2010/05/25 UR - http://n.首页neurology.org/content/74/21/1724.abstract N2 -背景:成像决定的空间扩散程度轻度神经胶质瘤(DLGGs)是非常重要的在评估手术切除的风险受益率。然而,目前尚不清楚准确的术前常规MRI如何描绘DLGGs。方法:我们报告回顾组织学和成像相关研究在16个成年病人串行立体定向活检诊断治疗幕上的定义和non-contrast-enhanced DLGG,在他检查后(OutBSs)内外MRI-defined异常。结果:37 OutBSs扩展从10 - 26毫米除了MRI-defined异常进行了研究。(即免疫染色显示MIB-1-positive细胞。、自行车OutBSs细胞)除了2。没有MIB-1-positive细胞coexpressed胶质原纤维酸性蛋白,它们coexpressed OLIG2。MIB-1-positive细胞循环孤立的肿瘤细胞,因为1)形态学特征反映了肿瘤细胞,2)每平方厘米MIB-1-positive细胞的数量明显高于控制,每平方厘米3)MIB-1-positive细胞数量呈正相关,肿瘤生长分数(p = 0.012),和4)每平方厘米MIB-1-positive细胞的数量与距离OutBSs减少肿瘤(p = 0.003)。结论:本研究表明,使用多尺度相关方法,常规MRI低估了实际空间的扩散程度轻度神经胶质瘤(DLGGs),即使他们划定。 These results suggest that an extended resection of a margin beyond MRI-defined abnormalities, whenever feasible in noneloquent brain areas, might improve the outcome of DLGGs. BS=biopsy sample; DLGG=diffuse low-grade glioma; FLAIR=fluid-attenuated inversion recovery; GFAP=glial fibrillary acidic protein; H1-MRSI=proton magnetic resonance spectroscopic imaging; InBS=biopsy sample taken inside MRI-defined abnormalities; ITC=isolated tumor cell; MR=magnetic resonance; NFP=neurofilament protein; OutBS=biopsy sample taken outside MRI-defined abnormalities. ER -