作者@article {Selter1711 ={司令部selt和f . Brilot诉Grummel诉克劳斯和美国Cepok司令部戴尔和缝边器},title ={抗体反应EBV和本地MOG小儿中枢神经系统炎性脱髓鞘疾病},体积={74}={21},页面= {1711 - 1715}= {2010},doi = {10.1212 / WNL。出版商0 b013e3181e04096} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:eb病毒(EBV)已经被讨论了作为一个可能的中枢神经系统炎性脱髓鞘疾首页病的病原体。大EBV与髓鞘蛋白已被建议作为一个潜在的机制EBV可能引起自身免疫反应针对中枢神经系统。最近,抗体滴度高,本机髓少突细胞糖蛋白(nMOG)被发现在孩子们第一个炎性脱髓鞘事件影响。抗体反应的关系EBV与儿童nMOG尚未解决。方法:我们调查nMOG抗体的出现,EBV核抗原1 (EBNA-1)和早期抗原(EA)在病例对照研究中包括儿童急性播散性脑脊髓炎(ADEM n = 19),患儿临床孤立综合征(CIS, n = 25),儿童与其他神经疾病(n = 28),和健康儿童(n = 30)。免疫球蛋白G(免疫球蛋白)和免疫球蛋白M (IgM)抗体的细胞外部分nMOG被细胞分析评估,和EBV-specific IgG抗体EBNA-1 IgM抗体ELISA EA进行评估。结果:血清免疫球蛋白抗体EBNA-1在场在43 \ %的控制(25/58),42 \ %的亚当(8/19),患儿和64 \ %的儿童与CIS(16/25),而IgM抗体EA发现只有16 \ %的ADEM的孩子(3/19)。高的抗体滴度nMOG只有在孩子ADEM和独联体但发现与EBV的血清阳性。此外,在EBV-seropositive孩子,我们没有观察到任何反{\ textendash} EBNA-1之间的相关性和anti-nMOG免疫球蛋白抗体滴度。 Conclusion: High serum immunoglobulin G titers to native myelin oligodendrocyte glycoprotein are found in a significant number of children affected by clinically isolated syndrome or acute disseminated encephalomyelitis. These antibodies are not related to the antibody response to Epstein-Barr virus. ADEM=acute disseminated encephalomyelitis; CIS=clinically isolated syndrome; EA=early antigen; EBNA-1=Epstein-Barr virus nuclear antigen 1; EBV=Epstein-Barr virus; HC=healthy controls; IgG=immunoglobulin G; IgM=immunoglobulin M; MFI=median fluorescence intensity; MOG=myelin oligodendrocyte glycoprotein; MS=multiple sclerosis; nMOG=native myelin oligodendrocyte glycoprotein; OD=optical density; OND=other neurologic diseases.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/74/21/1711}, eprint = {//www.ez-admanager.com/content/74/21/1711.full.pdf}, journal = {Neurology} }