% 0期刊文章% R.T.奈史密斯%许一个j . %一个台币Tutlam % p史高丽% k Trinkaus % A.Z.斯奈德%研究。歌% A.H.交叉% T扩散系数增加急性多发性硬化病变的风险预测黑洞% D R 10.1212 / WNL 2010%。0 b013e3181e042c4 % 首页J神经病学% P 1694 - 1701 X % V 74% N 21%目的:扩散张量成像(DTI)量化布朗运动组织内的水。炎症会导致组织损伤,导致增加扩散率和减少方向性。我们假设DTI可以量化的损害在急性多发性硬化症(MS)白质病变预测(Gd)钆增强病变T1 hypointensities将持续12个月后。方法:一群22个人接受7的大脑核磁共振扫描超过15个月。DTI参数区域内暂时量化Gd的提高。相比,同源区域的半球侧Gd-enhancing病变也执行规范个人病变DTI参数。分类后结果:每个Gd-enhancing区域黑洞的结果,径向扩散系数、扩散系数,和分数各向异性,连同他们的标准化值,显著改变了持久的黑洞(PBHs),提升整个研究。Gd-enhancing地区海拔在径向扩散系数为40% 5.4倍(95%可信区间[CI]: 2.1, 13.8)的风险增加成为PBH, 70% (95% CI: 51%、85%)敏感性和69% (95% CI: 57%、80%)特异性。 A model of radial diffusivity, with volume and length of Gd enhancement, was associated with a risk of becoming a PBH of 5.0 (95% CI: 2.6, 9.9). Altered DTI parameters displayed a dose relationship to duration of black hole persistence. Conclusions: Elevated radial diffusivity during gadolinium enhancement was associated with increased risk for development of a persistent black hole, a surrogate of severe demyelination and axonal injury. An elevated radial diffusivity within active multiple sclerosis lesions may be indicative of more severe tissue injury. ABH=acute black hole; CBH=chronic black hole; DTI=diffusion tensor imaging; FLAIR=fluid-attenuated inversion recovery; Gd=gadolinium; MS=multiple sclerosis; NAWM=normal-appearing white matter; PBH=persistent black hole; RD=radial diffusivity; ROI=region of interest; T1H=chronic T1 hypointensity; TBH=transient black hole. %U //www.ez-admanager.com/content/neurology/74/21/1694.full.pdf