RT期刊文章SR电子T1灰质和白质水扩散额颞叶痴呆综合征的变异的摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP 1279 1287 10.1212 / WNL OP。首页0 b013e3181d9edde VO 74是16 A1 J.L. Whitwell A1 r . Avula A1马丁Senjem A1 K。美国南达科他州Kantarci A1 Weigand A1。Samikoglu A1 H.A. Edmonson A1 p Vemuri A1科学博士Knopman A1背面Boeve A1司令部彼得森A1·约瑟夫A1 C.R.杰克,Jr .)年2010 UL //www.ez-admanager.com/content/74/16/127首页9.abstract AB目的:使用扩散张量成像(DTI)评估灰质和白质束扩散行为变异的额颞叶痴呆(bvFTD),语义痴呆(SMD),和进步的迟滞型失语症(PNFA)。方法:这是一个病例对照研究,16个受试者与bvFTD,与PNFA 7和4 SMD被年龄和性别识别和匹配到19控制。所有受试者3 t头部MRI和DTI在21个方向扩散编码序列。灰质是扩散系数(MD)评估使用的(ROI)和voxel-level方法,和分布形态测量学是用来评估模式的灰质的损失。白质束扩散系数(分数各向异性和径向扩散系数)是通过将roi评估在广阔的兴趣。结果:在bvFTD,增加灰质MD和灰质损失被确定双边在额叶和颞叶,异常扩散系数在白质束连接到这些地区。SMD、灰质损失和增加医学主要被确定在左颞叶,劣质纵束的路异常的观察和钩状的纤维束。PNFA,灰质损失和增加医学观察左额叶、岛叶,和补充运动区,在上纵束路异常的观察。 Conclusions: The diffusivity of gray matter is increased in regions that are atrophic in frontotemporal dementia, suggesting disruption of the cytoarchitecture of remaining tissue. Furthermore, damage was identified in white matter tracts that interconnect these regions, supporting the hypothesis that these diseases involve different and specific brain networks. AAL=automated anatomic labeling; AC=anterior cingulate; ADRC=Alzheimer's Disease Research Center; ADPR=Alzheimer's Disease Patient Registry; AOS=apraxia of speech; bvFTD=behavioral variant frontotemporal dementia; CV=coefficient of variation; DA=axial diffusivity; DR=radial diffusivity; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; FOV=field of view; FTD=frontotemporal dementia; FWHM=full-width at half-maximum; GCC=genu of the corpus callosum; HDW=high-dimensional warping; ILF=inferior longitudinal fasciculus; MD=mean diffusivity; MPRAGE=magnetization prepared rapid acquisition gradient echo; PC=posterior cingulate; PNFA=progressive nonfluent aphasia; PVC=partial volume correction; ROI=region of interest; SLF=superior longitudinal fasciculus; SMD=semantic dementia; UNC=uncinate fasciculus.

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