PT -期刊文章盟J.L. Whitwell AU - r . Avula AU -马丁Senjem AU - k Kantarci盟s.d Weigand AU - a . Samikoglu盟H.A. Edmonson AU - p . Vemuri盟科学博士Knopman盟直彼得森- B.F. Boeve盟盟-·约瑟夫盟C.R.杰克,Jr . TI -灰色和白色物质水扩散额颞叶痴呆综合征的变异的援助- 10.1212 / WNL。0 b013e3181d9edde DP - 2010年4月20日TA -神经首页病学第六PG - 1279 - 1287 - 74 IP - 16 4099 - //www.ez-admanager.com/content/74/16/1279.short 4100 - //www.ez-admanager.com/content/74/16/1279.full所以Neurology2010 4月20;74 AB -目的:使用扩散张量成像(DTI)评估灰质和白质束扩散行为变异的额颞叶痴呆(bvFTD),语义痴呆(SMD),和进步的迟滞型失语症(PNFA)。方法:这是一个病例对照研究,16个受试者与bvFTD,与PNFA 7和4 SMD被年龄和性别识别和匹配到19控制。所有受试者3 t头部MRI和DTI在21个方向扩散编码序列。灰质是扩散系数(MD)评估使用的(ROI)和voxel-level方法,和分布形态测量学是用来评估模式的灰质的损失。白质束扩散系数(分数各向异性和径向扩散系数)是通过将roi评估在广阔的兴趣。结果:在bvFTD,增加灰质MD和灰质损失被确定双边在额叶和颞叶,异常扩散系数在白质束连接到这些地区。SMD、灰质损失和增加医学主要被确定在左颞叶,劣质纵束的路异常的观察和钩状的纤维束。PNFA,灰质损失和增加医学观察左额叶、岛叶,和补充运动区,在上纵束路异常的观察。结论:灰质的扩散系数是提高地区萎缩性的额颞叶痴呆,表明剩余组织的细胞结构的破坏。 Furthermore, damage was identified in white matter tracts that interconnect these regions, supporting the hypothesis that these diseases involve different and specific brain networks. AAL=automated anatomic labeling; AC=anterior cingulate; ADRC=Alzheimer's Disease Research Center; ADPR=Alzheimer's Disease Patient Registry; AOS=apraxia of speech; bvFTD=behavioral variant frontotemporal dementia; CV=coefficient of variation; DA=axial diffusivity; DR=radial diffusivity; DTI=diffusion tensor imaging; FA=fractional anisotropy; FDR=false discovery rate; FOV=field of view; FTD=frontotemporal dementia; FWHM=full-width at half-maximum; GCC=genu of the corpus callosum; HDW=high-dimensional warping; ILF=inferior longitudinal fasciculus; MD=mean diffusivity; MPRAGE=magnetization prepared rapid acquisition gradient echo; PC=posterior cingulate; PNFA=progressive nonfluent aphasia; PVC=partial volume correction; ROI=region of interest; SLF=superior longitudinal fasciculus; SMD=semantic dementia; UNC=uncinate fasciculus.