PT -期刊文章盟硕士罗卡AU - p . Valsasina AU - m . Absinta AU - g . Riccitelli主机Rodegher盟盟- a - p . Misci AU - p·罗西盟Falini AU - g . Comi AU - m .菲利皮主持TI -静息状态网络功能障碍和认知障碍在进步的援助- 10.1212 / WNL女士。0 b013e3181d9ed91 DP - 2010年4月20日TA -神经首页病学第六PG - 1252 - 1259 - 74 IP - 16 4099 - //www.ez-admanager.com/content/74/16/1252.short 4100 - //www.ez-admanager.com/content/74/16/1252.full所以Neurology2010 4月20;74 AB -目的:本研究探讨静息状态网络(静)异常患者的二次进步(SP)和主进步(PP)多发性硬化症(MS)和这种异常是否与认知损伤和损伤选择白质纤维束(WM),量化使用扩散张量磁共振tractography (DT)。方法:静息状态(RS)功能性核磁共振和DT MRI从33 spm患者,获得的数据与项目组合管理系统24例,24控制。独立分量分析(ICA)是用来确定静。SPM5被用来评估中,群体间的激活。结果:静息活动差异被发现在左内侧前额叶皮质(mPFC)、左侧中央前回(PcG)和前扣带皮层(ACC)。控制相比,spm降低了患者的活动mPFC (p = 0.01)和PcG (p = 0.02),而项目组合管理系统降低了患者的活动PcG (p = 0.008)和ACC (p = 0.002)。项目组合管理系统的患者相比,spm患者增加了ACC活动(p = 0.04)。减少RS ACC的活动是在认知障碍与认知保存患者(p = 0.02)。女士,患者静息异常与PASAT的和单词表测试成绩(r值从0.35到0.45)和DT MRI变化胼胝体和瓣环(r值从0.82到0.87)。 Conclusion: These results suggest that a dysfunction of the anterior components of the default-mode network may be among the factors responsible for the accumulation of cognitive deficits in patients with progressive multiple sclerosis. ACC=anterior cingulate cortex; ANOVA=analysis of variance; CC=corpus callosum; CST=corticospinal tract; DMN=default-mode network; DT=diffusion tensor; EDSS=Expanded Disability Status Scale; EPI=echoplanar imaging; FA=fractional anisotropy; fMRI=functional MRI; FOV=field of view; ICA=independent component analysis; LV=lesion volume; MD=mean diffusivity; MDL=minimum description length; mPFC=medial prefrontal cortex; MS=multiple sclerosis; PASAT=Paced Auditory Serial Attention Test; PCA=principal component analysis; PCC=posterior cingulate cortex; PcG=precentral gyrus; PFC=prefrontal cortex; PP=primary progressive; ROCF=Rey-Osterrieth Complex Figure; RS=resting state; RSN=resting-state network; SP=secondary progressive; TE=echo time; tICA=tensorial ICA; TR=repetition time; TSE=turbo spin echo; WM=white matter.

map