作者@article {Rocca1252 ={硕士罗卡p . Valsasina和m . Absinta g . Riccitelli卷Rodegher和p . Misci p·罗西和a . Falini g . Comi m .菲利皮主持}title ={静息状态网络功能障碍和认知障碍在进步,},体积={74}={16},页面= {1252 - 1259}= {2010},doi = {10.1212 / WNL。出版商0 b013e3181d9ed91} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:本研究探讨静息状态网络(静)异常患者的二次进步(SP)和主进步(PP首页)多发性硬化症(MS)和这种异常是否与认知损伤和损伤选择白质纤维束(WM),量化使用扩散张量磁共振tractography (DT)。方法:静息状态(RS)功能性核磁共振和DT MRI从33 spm患者,获得的数据与项目组合管理系统24例,24控制。独立分量分析(ICA)是用来确定静。SPM5被用来评估中,群体间的激活。结果:静息活动差异被发现在左内侧前额叶皮质(mPFC)、左侧中央前回(PcG)和前扣带皮层(ACC)。控制相比,spm降低了患者的活动mPFC (p = 0.01)和PcG (p = 0.02),而项目组合管理系统降低了患者的活动PcG (p = 0.008)和ACC (p = 0.002)。项目组合管理系统的患者相比,spm患者增加了ACC活动(p = 0.04)。减少RS ACC的活动是在认知障碍与认知保存患者(p = 0.02)。 In patients with MS, DMN abnormalities correlated with the PASAT and word list test scores (r values ranging from 0.35 to 0.45) and DT MRI changes in the corpus callosum and the cingulum (r values ranging from 0.82 to 0.87). Conclusion: These results suggest that a dysfunction of the anterior components of the default-mode network may be among the factors responsible for the accumulation of cognitive deficits in patients with progressive multiple sclerosis. ACC=anterior cingulate cortex; ANOVA=analysis of variance; CC=corpus callosum; CST=corticospinal tract; DMN=default-mode network; DT=diffusion tensor; EDSS=Expanded Disability Status Scale; EPI=echoplanar imaging; FA=fractional anisotropy; fMRI=functional MRI; FOV=field of view; ICA=independent component analysis; LV=lesion volume; MD=mean diffusivity; MDL=minimum description length; mPFC=medial prefrontal cortex; MS=multiple sclerosis; PASAT=Paced Auditory Serial Attention Test; PCA=principal component analysis; PCC=posterior cingulate cortex; PcG=precentral gyrus; PFC=prefrontal cortex; PP=primary progressive; ROCF=Rey-Osterrieth Complex Figure; RS=resting state; RSN=resting-state network; SP=secondary progressive; TE=echo time; tICA=tensorial ICA; TR=repetition time; TSE=turbo spin echo; WM=white matter.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/74/16/1252}, eprint = {//www.ez-admanager.com/content/74/16/1252.full.pdf}, journal = {Neurology} }