TY - T1的隐球菌脑膜炎免疫活性的患者:变化趋势在加拿大JF -神经学乔-神经病学SP - 1233 LP - 1235 - 10.1212 / WNL。首页0 b013e3181d8c189六世- 74 - 15 AU -珍妮弗Bestard盟Zaeem a Siddiqi Y1 - 2010/04/13 UR - //www.ez-admanager.com/con首页tent/74/15/1233.abstract N2 -隐球菌病的范围可以从无症状的肺殖民致命的脑膜炎和传播疾病。大多数感染发生在免疫缺陷的州,尽管最近的报告表明,免疫活性的个体可能会与一些酵母品种风险。新型隐球菌var grubii和新型隐球菌var neoformans感染免疫力低下的个人,1,而新型隐球菌var gattii主要发生在免疫活性的病人和拥有强大的男性优势。这个品种是热带地区发现腐烂的心材的树种和爆发在2002年温哥华岛建议该地区的主要生态位的生物Canada.2迄今为止,没有例C neoformans var gattii免疫活性的不列颠哥伦比亚外病人已报告。我们从埃德蒙顿描述3这类患者的临床特征,阿尔伯塔省。案例报告。案例1。52岁以前健康的男人面对一个为期两天的历史发热、嗜睡,颈部僵硬。在前一个月,他经历过新出现头痛、日间极度嗜睡,减少流动性,和偶尔迷失方向,虽然例行调查,包括脑CT扫描,已经正常。 His family had moved from British Columbia in 2006. His HIV serology and chest X-ray were normal. CSF had lymphocytic pleocytosis. Brain CT showed hypodensities in basal ganglia, which appeared as multiple septated cysts (cryptococcoma) on MRI with no enhancement or surrounding edema (figure, A–F). CSF India ink stain was positive for cryptococcus and cultures grew C neoformans var gattii. Induction therapy with amphotericin B and flucytosine was instituted with daily lumbar punctures for raised … ER -