TY - T1的对比灰质和白质的变化临床亨廷顿疾病JF -神经学乔-神经病学SP - 1208 LP - 1216 - 10.1212 / WNL。首页0 b013e3181d8c20a六世- 74 - 15 AU - d Stoffers AU - s .谢耳朵盟盟J.M.库珀曼- j·戈尔茨坦AU - j . Corey-Bloom盟境Aron Y1 - 2010/04/13 UR - //www.ez-admanager.com/content/74/15/1208.abstr首页act N2 -背景:在亨廷顿病(HD),大量的纹状体萎缩先于临床运动症状。因此,神经保护应防止在这些症状出现之前主要的细胞损失。评估神经保护生物标记,如核磁共振的措施是必要的。这需要首先建立最好的成像方法。方法:采用横断面设计,我们收购了39的t1加权和diffusion-weighted扫描临床前(pre-HD)个人和25个年龄组。t1加权扫描分析了整个大脑分割总值和分布形态测量学。来diffusion-weighted扫描使用skeleton-based神经纤维束造影的分析。所有成像措施,我们pre-HD和对照组相比,pre-HD组我们检查相关性估计年内临床发作。结果:Pre-HD个人灰质(GM)生产总值(gdp)较低和白质体积(WM)。 Voxel-wise analysis demonstrated local GM volume loss, most notably in regions consistent with basal ganglia–thalamocortical pathways. By contrast, pre-HD individuals showed widespread reductions in WM integrity, probably due to a loss of axonal barriers. Both GM and WM imaging measures correlated with estimated years to onset. Conclusions: Using automated, observer-independent methods, we found that GM loss in pre-HD was regionally specific, while WM deterioration was much more general and probably the result of demyelination rather then axonal degeneration. These findings provide important information about the nature, relative staging, and topographic specificity of brain changes in pre-HD and suggest that combining GM and WM imaging may be the best biomarker approach. The empirically derived group difference images from this study are provided as regions-of-interest masks for improved sensitivity in future longitudinal studies. CAG=cytosine-adenine-guanine; EYO=estimated years to onset; FA=fractional anisotropy; FOV=field of view; GM=gray matter; HD=Huntington disease; MRI=magnetic resonance imaging; pre-HD=preclinical HD; TBSS=tract-based spatial statistics; TE=echo time; TI=inversion time; TR=repetition time; UCSD=University of California at San Diego; VBM=voxel-based morphometry; vCSF=ventricular CSF; WM=white matter. ER -