TY - T1的血清c反应蛋白与脑显微结构的完整性和认知功能JF -神经学乔-神经病学SP - 1022 LP - 1029 - 10.1212 / WNL。首页0 b013e3181d7b45b六世- 74 - 13非盟- h . Wersching AU - t .沙丘AU - h·罗曼AU - s穆罕默迪盟- c . Stehling盟- m . Fobker AU - m . Conty AU - j . Minnerup盟E.B. Ringelstein AU - k·伯杰AU - m . Deppe AU - s Knecht Y1 - 2010/03/30 UR - //www.ez-admanager.com/content/74/13/1022.abst首页ract N2 -目的:c反应蛋白是一种炎症和血管疾病的标志。它也似乎与痴呆的风险增加有关。为了更好地理解潜在的潜在机制,我们评估大脑显微结构的完整性和认知能力相对于血清高敏c反应蛋白水平(hs-CRP)。方法:我们横向比较分析了来自447个不同的生活小区,stroke-free系统评价和变更的个人认知健康的危险因素(搜索)健康研究(平均年龄63岁,248名女性)。轨迹MRI进行321年的主题。成像的措施包括fluid-attenuated反转恢复序列评估白质hyperintensities,自动定量诊断脑实质的卷,和扩散张量成像的计算全球和区域白质完整性、量化的分数各向异性(FA)。心理分析覆盖的非文字记忆,文字流畅,和执行功能。结果:高水平的hs-CRP在执行功能与性能下降后调整年龄、性别、教育、和心血管危险因素在多元回归分析(β=−0.095,p = 0.02)。此外,高hs-CRP有关减少全球分数各向异性(β=−0.237,p & lt; 0.001), as well as regional FA scores of the frontal lobes (β = −0.246, p < 0.001), the corona radiata (β = −0.222, p < 0.001), and the corpus callosum (β = −0.141, p = 0.016), in particular the genu (β = −0.174, p = 0.004). We did not observe a significant association of hs-CRP with measures of white matter hyperintensities or brain atrophy. Conclusion: These data suggest that low-grade inflammation as assessed by high-sensitivity C-reactive protein is associated with cerebral microstructural disintegration that predominantly affects frontal pathways and corresponding executive function. CRP=C-reactive protein; DTI=diffusion tensor imaging; FA=fractional anisotropy; FLAIR=fluid-attenuated inversion recovery; GMF=gray matter fraction; hs-CRP=high-sensitivity C-reactive protein; ROI=region of interest; SEARCH=Systematic Evaluation and Alteration of Risk Factors for Cognitive Health; TE=echo time; TI=inversion time; TR=repetition time; WM=white matter; WMF=white matter fraction; WMH=white matter hyperintensities. ER -