TY -的T1 -扩散张量磁共振成像小脑结构变化的家族性特发性震颤患者JF -神经学乔-神经病学SP - 988 LP - 994 - 10.1212 / WNL。首页0 b013e3181d5a460六世非盟- 74 - 12 - g . Nicoletti AU - d礼仪盟- f·诺维利诺盟- f . Condino AU - e . Malucelli盟- b . Barbiroli盟- c Tonon AU - g .阿拉伯AU - m . Salsone AU - l . Giofre”非盟- c .甲壳盟- p .兰扎非盟- r·洛迪盟- a•夸特隆Y1 - 2010/03/23 UR - //www.ez-admanager.com/content/74/12/988.abstract N2 -目的:我们研究的目的是首页调查的显微结构的完整功能的大脑区域参与地震循环家族性特发性震颤患者(场效应晶体管),使用扩散张量成像(DTI)。方法:患者25场效应晶体管,15帕金森病(PD)患者,15名健康受试者的研究。DTI进行测量分数各向异性(FA)和平均扩散系数(MD)在不同地区的利益:红核、齿状核(DN)、小脑白质,中间(MCP)和优越的小脑脚(SCP)和腹外侧丘脑。结果:患者的场效应晶体管,DN的FA值(平均0.19,0.13 - -0.23)减少(p & lt;0.001)与PD患者(平均0.37,0.32 - -0.58)和健康对照组(平均0.36,0.33 - -0.40)。患者的场效应晶体管,足协也降低(p = 0.003)和MD值增加(p & lt;0.001)在SCP与PD患者和健康对照组相比。场效应晶体管的患者,病程长的患者显示在DN FA值低于疾病持续时间较短(p = 0.018)。场效应晶体管的患者可以完全有别于PD患者和健康对照组使用FA值的DN。 Conclusion: Neuroimaging evidence of microstructural changes consistent with neurodegeneration was found in the dentate nucleus (DN) and SCP of patients with familial essential tremor. This suggests that neurodegenerative pathology of cerebellar structures may play a role in essential tremor. Further studies are needed to assess the role of fractional anisotropy and mean diffusivity changes in DN and SCP in the differential diagnosis of essential tremor and Parkinson disease, which may present similar clinical signs at the onset of disease. ADC=apparent diffusion coefficient; DN=dentate nucleus; DTI=diffusion tensor imaging; EPI=echo planar imaging; ET=essential tremor; FA=fractional anisotropy; Fahn-TRS-A=Fahn-Tolosa-Martin Tremor Rating Scale, Part A; FET=familial essential tremor; MCP=middle cerebellar peduncle; MD=mean diffusivity; PD=Parkinson disease; ROI=region of interest; SCP=superior cerebellar peduncle. ER -