RT期刊文章SR电子T1脑脊液神经胶质标记与生存在肌萎缩性脊髓侧索硬化症摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 982 OP 987 10.1212 / WNL。首页0 b013e3181d5dc3b VO 74是12 A1 s d . Sussmuth A1。d . Sperfeld A1。海因茨A1 j . Brettschneider A1 s Endruhn A1。c Ludolph A1 h . Tumani年2010 UL http://n.neu首页rology.org/content/74/12/982.abstract AB背景:在神经退行性疾病如肌萎缩性脊髓侧索硬化症(ALS),脑脊液生物标志物越来越为鉴别诊断评估他们的相关性,研究疾病进展,对病理生理的过程的理解。目的:确定一个生物标记的神经元和神经胶质脑脊液蛋白歧视ALS与其他运动神经元病(MND),并评估基线水平的ALS CSF措施是否与课程相关的疾病。方法:连续共有122名受试者MND是包含在这个横断面研究(肌萎缩性侧索硬化症,n = 75;下运动神经元综合症,n = 39;上运动神经元疾病,n = 8)。临床随访包括76例。我们确定基线水平的蛋白质τ和astroglial S100beta CSF和小胶质sCD14脑脊液和血清与诊断、疾病、持续时间和生存。结果:脑脊液τ显著升高在ALS和上运动神经元疾病相比下运动神经元疾病和控制。 CSF S100beta levels were significantly lower in lower motor neuron diseases as compared to other MND. CSF concentrations of S100beta and sCD14 correlated with the survival time in patients with ALS. Conclusions: In motor neuron diseases, CSF tau elevation indicates the degeneration of upper motor neurons, while S100 beta and sCD14 may indicate the activation of CNS glial cells. Because S100beta and sCD14 concentrations correlate with survival in amyotrophic lateral sclerosis (ALS), we suppose that the combination of both markers may be useful to obtain prognostic information in patients with ALS. ALS=amyotrophic lateral sclerosis; ALSFRS=Amyotrophic Lateral Sclerosis Functional Rating Scale; HSP=hereditary spastic paraplegia; LMN=lower motor neuron; LMND=lower motor neuron disease; MND=motor neuron disease; MRCS=Medical Research Council Sumscore; PLS=primary lateral sclerosis; ROC=receiver operating characteristic; UMN=upper motor neuron.

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