TY - T1的认知下降事件阿尔茨海默病在一个社区人口JF -神经学乔-神经病学SP - 951 LP - 955 - 10.1212 / WNL。首页0 b013e3181d64786六世- 74 - 12非盟- r·s·威尔逊盟n . t . Aggarwal AU - l·l·巴恩斯AU - c·f·门德斯德莱昂AU - l·e·赫伯特AU - d·a·埃文斯Y1 - 2010/03/23 UR - //www.ez-admanager.com/content/74/12/951.abstract N首页2 -目的:测量事件的认知影响阿尔茨海默病(AD)在老年黑人和白人的主题。方法:数据来自芝加哥健康和衰老项目,年长的白人和黑人的纵向队列研究的人居住在一个社区定义的地理位置。每隔三年,整个研究人口4短暂的认知测试,完成从一个先前建立的复合测量全球认知,和一个子集进行详细的临床评价,支持轻度认知障碍的临床分类,痴呆和广告。我们使用mixed-effects模型来检查诊断评估后认知功能改变。结果:在临床评估,614人被发现没有认知障碍,395有轻度认知障碍,和149年广告(温和的88.5%);10人与其他痴呆被排除在分析之外。During up to 11 years of observation following the clinical evaluation (mean = 5.5, SD = 2.5), the composite measure of global cognition declined a mean of 0.042 unit per year (SE = 0.008, p < 0.001) in those with no cognitive impairment. In comparison to the no cognitive impairment group, the annual rate of decline was increased more than twofold in mild cognitive impairment (estimate = 0.086, SE = 0.011, p < 0.001) and more than fourfold in AD (estimate = 0.173, SE = 0.020, p < 0.001). Results did not reliably vary by race, sex, or age. Conclusions: Alzheimer disease has a devastating impact on cognition, even in its prodromal stages, with comparable effects in African American and white persons. AD=Alzheimer disease; MCI=mild cognitive impairment. ER -