RT期刊文章SR电子T1血浆置换急性中枢神经系统脱髓鞘的摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 949 OP 953 10.1212 / W首页NL。0 b013e3181b879be VO 73是12 A1 s Llufriu A1 j·卡斯蒂略A1 y布兰科A1 l . Ramio-Torrenta A1 j .里约热内卢A1 m .水手A1 m . Lozano A1 m . d . Castella A1 j . Calabia A1。Horga A1 F。格劳A1 x好吃的A1。Saiz年2009 UL http://n.neu首页rology.org/content/73/12/949.abstract AB背景:血浆置换(PE)用于治疗严重的中枢神经系统脱髓鞘反应迟钝的糖皮质激素。预测长期的反应并不是众所周知的。方法:我们回顾了41名患者的医疗记录连续治疗PE 1995年1月至2007年7月。主要结果是在6个月后改善PE定义为减少≥1点的扩大残疾状态量表(eds)评分对患者eds≤7.5或1.5点与eds≥8.0或改善视力的超过2行图表患者视神经炎(上)。结果:25例(61%)是女性,平均年龄是33年(范围14-57年)。23例(56%)有多发性硬化症,2例(5%)临床孤立综合征,2例(5%)有马尔堡病,7例(17%)有急性播散性脑脊髓炎,4例(10%)有视neuromyelitis, 2特发性(5%),1例(2%)有特发性横向脊髓炎。攻击前的eds得分中值为1.0(范围0 - 6.5)。 At PE onset, the median EDSS score was 7.0 (range 3.0–9.5). Sixteen patients (39%) improved at discharge, and 26 (63%) improved at 6 months. In the multivariate analysis, early initiation of PE (odds ratio [OR] 6.29, 95% confidence interval [CI] 1.18–52.96) and improvement at discharge (OR 7.32, 95% CI 1.21–44.38) were significantly associated with response at 6 months. Conclusions: Plasma exchange (PE) was associated with clinical improvement in 63% of patients at 6 months. Early initiation of PE and improvement at discharge were predictors of this response. Twelve patients (48%) who did not improve early did so during follow-up. CI=confidence interval; CIS=clinically isolated demyelinating syndrome; EDSS=Expanded Disability Status Scale; MS=multiple sclerosis; NA=not applicable; NMO=neuromyelitis optica; non-MS=excludes multiple sclerosis and clinically isolated syndrome; ON=optic neuritis; OR=odds ratio; PE=plasma exchange; VA=visual acuity.

map