% 0期刊文章% s Llufriu % j·卡斯蒂略%一个y .布兰科% l . Ramio-Torrenta % j .里约热内卢% m .水手% m . Lozano % m . D . Castella % j . Calabia % A . Horga % f·格劳% x好吃% A . Saiz % T血浆置换为急性中枢神经系统脱髓鞘% B的攻击预测的改进在6个月% D R 10.1212 / WNL 2009%。0 b013e3181b879be % 首页J神经病学% P 949 - 953 V % 73% 12% N X背景:血浆置换(PE)用于治疗严重的中枢神经系统脱髓鞘反应迟钝的糖皮质激素。预测长期的反应并不是众所周知的。方法:我们回顾了41名患者的医疗记录连续治疗PE 1995年1月至2007年7月。主要结果是在6个月后改善PE定义为减少≥1点的扩大残疾状态量表(eds)评分对患者eds≤7.5或1.5点与eds≥8.0或改善视力的超过2行图表患者视神经炎(上)。结果:25例(61%)是女性,平均年龄是33年(范围14-57年)。23例(56%)有多发性硬化症,2例(5%)临床孤立综合征,2例(5%)有马尔堡病,7例(17%)有急性播散性脑脊髓炎,4例(10%)有视neuromyelitis, 2特发性(5%),1例(2%)有特发性横向脊髓炎。攻击前的eds得分中值为1.0(范围0 - 6.5)。在PE发作,eds得分中位数是7.0(范围3.0 - -9.5)。16例(39%)提高放电,26(63%)在6个月的改善。在多变量分析中,应及早PE(比值比(或)6.29,95%可信区间[CI] 1.18 - -52.96)和改善放电(或7.32,95%可信区间1.21 - -44.38)显著相关的响应在6个月。 Conclusions: Plasma exchange (PE) was associated with clinical improvement in 63% of patients at 6 months. Early initiation of PE and improvement at discharge were predictors of this response. Twelve patients (48%) who did not improve early did so during follow-up. CI=confidence interval; CIS=clinically isolated demyelinating syndrome; EDSS=Expanded Disability Status Scale; MS=multiple sclerosis; NA=not applicable; NMO=neuromyelitis optica; non-MS=excludes multiple sclerosis and clinically isolated syndrome; ON=optic neuritis; OR=odds ratio; PE=plasma exchange; VA=visual acuity. %U //www.ez-admanager.com/content/neurology/73/12/949.full.pdf