作者@article {Llufriu949 ={年代。Llufriu j·卡斯蒂略和y .布兰科l . Rami {\ ' o}洪流{\ '},j . R{\ \我}o和m . Vall {} \ ' e s和m . Lozano和m . d .名卡斯特尔{\ '}和j . Calabia a Horga f·格劳和x好吃的a . Saiz} title ={等离子换取急性中枢神经系统脱髓鞘},体积={73}={12},页面= {949 - 953}= {2009},doi = {10.1212 / WNL。出版商0 b013e3181b879be} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:血浆置换(PE)用于治疗严重的中枢神经系统脱髓鞘反应迟钝的糖皮质激素首页。预测长期的反应并不是众所周知的。方法:我们回顾了41名患者的医疗记录连续治疗PE 1995年1月至2007年7月。主要结果是在6个月后改善PE定义为减少> = 1点的扩大残疾状态量表(eds)患者得分eds < = 7.5或1.5分,eds > = 8.0或改善视力的超过2行图表患者视神经炎(上)。结果:25例(61 \ %)是女性,平均年龄是33年(范围14 {\ textendash} 57年)。23(56 \ %)多发性硬化症,2(5 \ %)临床孤立综合征,2(5 \ %)马尔堡病,7(17 \ %)急性播散性脑脊髓炎,4(10 \ %)视neuromyelitis, 2(5 \ %)特发性,和1(2 \ %)特发性横向脊髓炎。攻击前的eds得分中值为1.0(6.5范围0 {\ textendash})。在PE发作,eds得分中位数是7.0(范围3.0 9.5 {\ textendash})。16例(39 \ %)改善排放,和26(63 \ %)在6个月的改善。 In the multivariate analysis, early initiation of PE (odds ratio [OR] 6.29, 95\% confidence interval [CI] 1.18{\textendash}52.96) and improvement at discharge (OR 7.32, 95\% CI 1.21{\textendash}44.38) were significantly associated with response at 6 months. Conclusions: Plasma exchange (PE) was associated with clinical improvement in 63\% of patients at 6 months. Early initiation of PE and improvement at discharge were predictors of this response. Twelve patients (48\%) who did not improve early did so during follow-up. CI=confidence interval; CIS=clinically isolated demyelinating syndrome; EDSS=Expanded Disability Status Scale; MS=multiple sclerosis; NA=not applicable; NMO=neuromyelitis optica; non-MS=excludes multiple sclerosis and clinically isolated syndrome; ON=optic neuritis; OR=odds ratio; PE=plasma exchange; VA=visual acuity.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/73/12/949}, eprint = {//www.ez-admanager.com/content/73/12/949.full.pdf}, journal = {Neurology} }