RT期刊文章SR电子T1神经系统疾病流行的hiv阳性的门诊病人在亚太地区摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 50 OP 56做10.1212/01. wnl.0000316390.17248.65 VO 7首页1是1 A1 e·赖特A1 b酿造A1。Arayawichanont A1 K。罗伯逊A1 K。Samintharapanya A1 s Kongsaengdao A1 m . Lim A1 s Vonthanak A1 l . Lal A1 c Sarim A1 s Huffam A1 p .李A1 d·伊姆兰A1 j·刘易斯A1 W。h . Lun A1。Kamarulzaman A1 g .τA1 s t·阿里A1 K。德怀尔基肖尔A1 m·p·贝恩A1 r . A1 g·麦科马克A1 m . Hellard A1 c .樱桃A1 j·麦克阿瑟A1 Wesselingh年2008 UL //www.ez-admanager.com/content/71/1/50.abstr首页act AB背景:共有830万艾滋病病毒试验呈阳性的人住在亚太地区。艾滋病毒相关神经认知障碍和感觉神经病变症状的负担在这个区域是未知的。方法:2005年7月至2006年3月,我们进行了横断面研究10哨兵地点在八亚太国家确定中度到重度的患病率与艾滋病毒相关的神经认知障碍和感觉神经病变症状。我们临床评估和管理敏感的神经心理学和周围神经病变筛查工具,658名患者感染了艾滋病毒。 Univariate and logistic regression analyses were applied to the data. Results: The results showed that 76 patients (11.7%) (95% CI 9.3–14.2) were significantly neurocognitively impaired, 235 patients (36.4%) (95% CI 32.7–40.2) were depressed, and 126 patients (19.7%) (95% CI 16.6–22.8) had either definite or probable symptomatic sensory neuropathy; 63% of this last group had exposure to stavudine, didanosine, or zalcitabine. Several potential confounders including depression (OR 1.49, 95% CI 0.88–2.51, p = 0.11) and prior CNS AIDS illness (OR 1.28, 95% CI 0.50–2.89, p = 0.54) were not significantly associated with neurocognitive impairment. Conclusions: A total of 12% of patients had moderate to severe HIV-related neurocognitive impairment, 20% of patients had symptomatic sensory neuropathy, and 36% of patients had evidence of depression. This study provides a broad regional estimate of the burden of HIV-related neurologic disease and depression in the Asia-Pacific region. AP=Asia-Pacific; APNAC=Asia Pacific NeuroAIDS Consortium; ARV=antiretroviral; CES-D=Center for Epidemiologic Studies-Depression Scale; HAART=highly active antiretroviral therapy; HAD=HIV-associated dementia; NCI=neurocognitive impairment; SN=sensory peripheral neuropathy.

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