RT期刊文章SR电子T1帽子分数摩根富林明神经学神经学乔FD Lippincott Williams &威首页尔金斯SP 1417 OP 1423做wnl.0000330297.58334 10.1212/01.。dd VO 71 A1是18 m .卢A1。Safdar A1 Kumar A1 g . m . Mehdiratta A1 Schlaug A1 l . Caplan A1 d Searls A1 m·斯莱姆年2008 UL http://n.neurolo首页gy.org/content/71/18/1417.abstract AB目标:开发一个分级规模预测脑出血的风险(我)和治疗后的预后与IV tissue-plasminogen活化剂(t-PA)在缺血性中风患者。方法:我们构建了一个五点量表基于NIH卒中量表得分,hypodensity程度在CT扫描,在基线血清葡萄糖,糖尿病的历史来预测溶栓后出血的风险(帽子得分)。我们评估这种规模的预测能力,使用c-statistics,在两个独立的人群:t-PA治疗组在国家神经疾病和中风研究所的研究,和患者连续IV t-PA在我们机构。结果:患者的百分比任何我t-PA后增加两组得分越高。总的来说,任何出血症状的比率为2%(0点),5%(1分),10%(2分),15%(3分),44%(> 3分)。c-statistic为0.72 (95% CI 0.65 - -0.79;所有出血p < 0.001);0.74 (0.63 - -0.84;出血症状p < 0.001); and 0.79 (0.70–0.88; p < 0.001) for hemorrhages with final fatal outcome. Similar results were obtained when each cohort was analyzed separately. The score also reasonably predicted good (mRS ≤ 2) (c-statistic 0.75; 0.69–0.80; p < 0.001) and catastrophic (mRS ≥ 5) (0.78; 0.72–0.84; p < 0.001) functional outcomes on day 90 in the National Institute of Neurological Disorders and Stroke t-PA-treated patients. Conclusions: The hemorrhage after thrombolysis (HAT) score is a practical, quick, and easy-to-perform scale that allows reasonable risk stratification of intracerebral hemorrhage after IV tissue-plasminogen activator (t-PA). However, the prognostic value of this scale and its use to predict the net benefit from t-PA needs to be refined and prospectively confirmed in a larger cohort of patients before it can be used in clinical decision-making. AIS=acute ischemic stroke; DWI=diffusion-weighted imaging; HAT score=hemorrhage after thrombolysis score; HFFO=hemorrhage with final fatal outcome; IA=intra-arterial; ICH=intracerebral hemorrhage; MCA=middle cerebral artery; mRS=modified Rankin Score; NIHSS=National Institutes of Health Stroke Scale; NINDS=National Institute of Neurological Disorders and Stroke; ROC=receiver-operator curves; SICH=symptomatic ICH; t-PA=tissue-plasminogen activator; TPI=Thrombolytic Predictive Instrument.

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