% 0期刊文章%一个j . D . Sluimer % h . Vrenken % m·A . Blankenstein % n·c·福克斯% p . Scheltens % f . Barkhof %一个w·m·范德传单% T阿尔茨海默病整个大脑萎缩率% B快速识别不寻常% D R 10.1212/01. wnl.0000311446.61861 2008%。e3 % J首页神经病学% P 1836 - 1841 V % 70% N X 19 2%部分目的:评估基线临床和MRI措施影响整个大脑萎缩率,测量从串行成像先生。方法:我们招募了65名老年痴呆症患者(平均±标准差70±8岁y, 58%女性,细微精神状态检查(MMSE) 22±5),扫描平均间隔为1.7±0.6年。整个大脑萎缩率作为测量结果。基线规范化的脑容量,海马体积,和整个大脑萎缩率测量使用三维t1加权成像。的影响,年龄、性别、载脂蛋白E基因型(APOE),基线MMSE,海马体积基线,基线规范化脑容量整个大脑萎缩率是评估使用线性回归。结果:意思是整个大脑萎缩率每年−1.9±0.9%。在多变量模型中,年轻的年龄(β(SE) = 0.03 (0.01);p = 0.04),缺乏APOEε4(β(SE) = 0.61 (0.28);p = 0.03)和较低的MMSE(β(SE) = 0.11 (0.03);p < 0.001),与整个大脑萎缩率较高。 Furthermore, a relatively spared hippocampus predicted faster decline for patients with a smaller baseline brain volume (p = 0.09), and with a lower MMSE (p = 0.07). Finally, a smaller brain volume was associated with a higher rate of atrophy in younger patients (p = 0.03). Conclusions: Our results suggest it is possible to characterize a subgroup of patients with Alzheimer disease (AD) who are at risk of faster loss of brain volume. Patients with more generalized, rather than focal hippocampal atrophy, who often have an onset before the age of 65, and are APOE ε4 negative, seem to be at risk of faster whole-brain atrophy rates than the more commonly seen patients with AD, who are older, are APOE ε4 positive, and have pronounced hippocampal atrophy. AD=Alzheimer disease; MMSE=Mini-Mental State Examination; NBV=normalized baseline brain volume; PBVC=percentage brain volume change. %U //www.ez-admanager.com/content/neurology/70/19_Part_2/1836.full.pdf

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