PT -期刊文章盟j . m . Olichney AU - j·r·泰勒AU - j . Gatherwright AU - d . p .鲑鱼盟盟——m·a·j·布雷斯勒库塔AU - v . j . Iragui-Madoz TI - MCI患者N400和P600异常转换为痴呆风险非常高的援助——wnl.0000281689.28759 10.1212/01.。ab DP - 2008 1770年5月06 TA首页 -神经病学PG - 1763——第2部分VI - 70 IP - 19 4099 - //www.ez-admanager.com/content/70/19_Part_2/1763.short 4100 - //www.ez-admanager.com/content/70/19_Part_2/1763.full所以Neurology2008可能06;70 AB -目的:我们寻求认知与事件相关电位(ERP)的生物标志物疾病进展和随后的转换在轻度认知障碍(MCI)痴呆。背景:两个ERP组件,P600和N400敏感异常情景/陈述性记忆和语义处理。谐调category-exemplars重复时,小P600s(相对于初始)通常引起。重复语义上不协调的单词产生较小的N400振幅。在轻度阿尔茨海默病(AD),异常的N400和P600重复效应存在,表明突触可塑性的一个普遍的失败。方法:患者遗忘MCI (n = 32)与ERP每年纵向研究范式中,语义一致的(50%)和不协调的目标词是重复10到140秒后的首次演讲。ERP数据分析对比MCI-to-AD转换器(3年内)vs nonconverters使用裂区分析的方差。结果:统计上显著的P600一致的词重复效应被发现只有nonconverter组(F = 9.9, p = 0.005 vs MCI转换器)。这种效应与非文字记忆相关的措施。 Repetition of incongruous words produced a significant N400 amplitude attenuation (across right-hemisphere sites) in nonconverters, but not in converters. Patients with MCI with abnormal/reduced N400 or P600 word repetition effects had an 87 to 88% likelihood of dementia within 3 years while those with normal/spared N400 and P600 repetition effects had only an 11 to 27% likelihood. Conclusions: Abnormalities of the P600 or N400 in mild cognitive impairment are associated with an increased risk of subsequent conversion to Alzheimer disease (AD). These event-related potential components may offer useful biomarkers for the detection and staging of very early AD. AD=Alzheimer disease; ADRC=Alzheimer’s Disease Research Center; ANOVA=analyses of variance; CDR=Clinical Dementia Rating scale; CVLT=California Verbal Learning Test; ERP=event-related potential; LPC=late positive component; MCI=mild cognitive impairment; MMSE=Mini-Mental State Examination; PPV=positive predictive value; UCSD=University of California, San Diego.