TY -的T1的随机试验rizatriptan儿童偏头痛发作JF -神经学乔-神经病学SP - 1135 LP - 1140——10.1212/01. wnl.000023首页8179.79888.44六世- 67 - 7 AU - k . Ahonen盟- m . l . Hamalainen AU - m . Eerola AU - k Hoppu Y1 - 2006/10/10 UR - //www.ez-admanager.com/content/67/7/1135.abstract N2 -目的:检查rizatriptan的疗效和治疗反应的一致性在偏头痛发作的儿童和青少年。方法:我们进行了一项双盲,安慰剂对照的三方交叉试验6岁至17岁的病人在两个医院儿科门诊诊断为偏头痛。两剂rizatriptan在家和一个匹配的安慰剂管理在三个攻击。Rizatriptan 5毫克剂量对于20到39公斤的体重,和10毫克的体重40公斤以上。主要疗效终点是头痛缓解由两个等级规模五程度的脸在2小时。结果:九十六例患者使用所有三个治疗,10个使用了两个,10只。在2小时,主要终点是达到两倍rizatriptan治疗后(第一次74%,n = 71/96;第二个73%,n = 70/96)后作为安慰剂(36%,n = 35/96) (p & lt;0.001)。已经在1小时,rizatriptan显然是更有效的减缓头痛是50%(48/96)和55%(53/96例)的儿童rizatriptan第一和第二剂量后,相比29% (n = 28/96)安慰剂(p = 0.004)。 Rizatriptan was superior at 3 and 4 hours, and the other endpoints also favored rizatriptan. Efficacy of rizatriptan was constant over the two treated attacks, and the findings were similar in children using the dose of 5 and 10 mg. No serious adverse effects were observed. Conclusions: Oral rizatriptan is effective and well-tolerated for migraine attacks in children over age 6 years. ER -