PT -期刊文章盟t .西方非盟- m·怀亚特盟a高盟——a·博斯特罗姆盟大肠Waubant TI -初始脱髓鞘事件恢复和微分控制时间的第二个事件?援助——wnl.0000234031.30756 10.1212/01.。a0 DP - 2006年9月12日TA -神经病首页学第六PG - 809 - 813 - 67 IP - 5 4099 - //www.ez-admanager.com/content/67/5/809.short 4100 - //www.ez-admanager.com/content/67/5/809.full所以Neurology2006 9月12;67 AB -背景:复发缓和多发性硬化(名RRMS)始于最初的脱髓鞘事件(IDE)可以单症状的,polysymptomatic或polyregional。未能从IDE中恢复是一种已知的预测后来发展的障碍。因素,预测IDE恢复(外视神经炎)和第二事件相对不知名的时间。作者推测,IDE复苏时间和第二个事件独立的生物或基因控制,这样,他们的临床预测因素是不同的。方法:数据在所有UCSF医学诊所的病人是进入预期到一个访问数据库。作者发现所有患者在1年内UCSF诊所的IDE。扩大残疾状态量表得分,得分功能系统,视力也用来定义IDE严重程度和恢复。 Results: The cohort included 186 patients (127 women, 59 men) with an average onset age of 34 ± 10 years with 150 whites (non-Hispanic), 15 African Americans, 11 Hispanics, eight Asians, and two unknown/unreported. Worse onset severity predicted worse IDE recovery (23.1% of the patients with severe onset vs 32.9% with moderate severity vs 56.4% with mild onset recovered completely, p < 0.001). Polyregional onset predicted poor recovery compared to monoregional onset (46.2% vs 14.4%, p < 0.001). Nonwhite patients were 2.48 times more likely than whites to experience a second episode within 1 year from onset (95% CI: 1.45 to 4.23, p < 0.001). Similarly, age younger than 30 years predicted higher risk of a second exacerbation (hazard ratio 1.92, 95% CI: 1.17 to 3.15, p = 0.010). Conclusion: Initial demyelinating event recovery and time to second event may have distinct predictors. These findings suggest that recovery and time to second event might be under separate biologic control.

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