@article {= {Mary l . Zupanc},作者ZupancS37 title ={抗癫痫药物和激素避孕在青少年女性癫痫},体积={66},数量={66,85},页面= {S37——S45} = {2006}, doi = {10.1212 / WNL.66.66_suppl_3。出版商S37} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={雌激素和孕激素的影响在女性癫痫发作活动,一般与雌激素展示proconvuls首页ant和孕激素抗惊厥的作用。女性癫痫表现出多种内分泌干扰,可能由于多种因素,包括癫痫综合征和发作和发作的癫痫放电的影响。某些抗癫痫药物(aed)的直接影响进一步增加这种风险,显然与一个特定的药物{\ textquoteright}年代影响肝微粒体酶的细胞色素p - 450系统。aed,从而诱导肝微粒体酶也与激素避孕增加雌激素{\ textquoteright}新陈代谢和黄体酮{\ textquoteright}年代蛋白结合,降低浓度的激素,从而降低避孕效果。一些证据表明,并发使用激素避孕和拉莫三嗪显著减少拉莫三嗪的血浆浓度,建议密切监测是十分必要的。然而,荷尔蒙避孕授予可比或优越的功效与宫内节育器和障碍等其他避孕方法并与癫痫女性仍是一个适当的选择。重要的是,并发使用激素避孕和aed并不影响癫痫控制。小心病人管理,包括使用增加雌激素剂量(> = 50μg)在接受enzyme-inducing aed的病人,可能会进一步减少意外怀孕的风险。育龄妇女的特殊注意事项包括减少合规和疾病预防。 Although adequate seizure control is the critical requirement of an AED, the potential for interactions with hormonal contraception and the increased risk for endocrine disturbances caused by drugs that alter hepatic microsomal enzymes suggest additional potential advantages for AED treatment that does not affect these enzymes. Both the constellation of physicians treating women with epilepsy and the patients themselves have a poor understanding of the spectrum of reproductive health issues involved, and increased awareness is needed to improve patient management.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/66/66_suppl_3/S37}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }