TY -的T1 -等离子体β-amyloid和白质病变广告,MCI,和脑淀粉样血管病JF -神经学乔-神经病学SP - 23 LP - 29 - 10.1212/01. wnl.0000191403.95453.首页6a六世- 66 - 1 AU - m . e . Gurol盟m . c .伊瑞盟- e·e·史密斯盟- s Raju盟- r . Diaz-Arrastia AU - t . Bottiglieri AU - j . Rosand AU - j . h . Growdon AU - s·m·格林伯格Y1 2006/01/10 UR - //www.ez-admanager.com/content/66/1/23.abstract N2 -背景:微血管脑损伤,通常衡量(负责人)MRI的白质高密度,是一个重要的因素在老年人认知障碍。最近的研究表明循环β-amyloid肽的作用在微血管功能障碍和脑白质病。方法:作者进行了横断面研究的临床、生化、遗传因素相关负责人在54个科目与阿尔茨海默病(AD)或轻度认知障碍(广告/ MCI)和一个独立组42受试者脑淀粉样血管病(CAA)。负责人的程度是由计算机辅助体积测量规范化颅内大小(nWMH)。40 -生化测量包括等离子体浓度和42-amino酸种β-amyloid (Aβ40和Aβ42)检测到特定的酶联免疫吸附试验。结果:等离子Aβ40浓度与两组nWMH相关(相关系数= 0.48在广告/ MCI,创新艺人经纪公司的0.42,p≤0.005)。等离子体Aβ40保持独立与nWMH调整后潜在的混杂因素在年龄、高血压、糖尿病、同型半胱氨酸,肌酸酐,叶酸,维生素B12, APOE基因型。腔隙性梗死灶的存在也与两组Aβ40增加有关。nWMH比广告在CAA(19.8立方厘米)(11.1立方厘米)或MCI(10.0立方厘米;p & lt; 0.05 for both comparisons). Conclusions: Plasma β-amyloid 40 concentration is independently associated with extent of white matter hyperintensity in subjects with Alzheimer disease, mild cognitive impairment, or cerebral amyloid angiopathy. If confirmed in longitudinal studies, these data would suggest circulating β-amyloid peptide as a novel biomarker or risk factor for microvascular damage in these common diseases of the elderly. ER -