PT -期刊文章盟格劳瑟t . a . AU - r·阿亚拉盟r . d . Elterman盟——w·g·米切尔盟——c·b·范·奥盟- l . j .高斯AU - z Lu ED, TI -双盲安慰剂对照试验的辅助levetiracetam儿科部分癫痫发作援助- 10.1212/01. wnl.0000217916.00225.3a DP - 2006 6月13 TA -神经病学第六PG - 1654 - 1660 - 66 IP - 11 4099 - //www.ez-admanager.com/content/66/11/1654.short 4100 - //www.ez-admanager.com/cont首页ent/66/11/1654.full所以Neurology2006 6月13;66 AB -目的:评估levetiracetam的疗效和耐受性(LEV)作为辅助治疗儿童(4至16年)难治性部分性癫痫发作。方法:多中心、随机、安慰剂对照试验包括基线期8周后尽早双盲治疗期。在治疗期间,患者接受安慰剂或LEV附加疗法和up-titrated目标剂量的60毫克/公斤/天。结果:一百九十八例患者(intent-to-treat人口)提供可评价的数据。减少的部分性发作频率每周列弗辅助疗法辅助治疗在安慰剂显著(26.8%;p = 0.0002;95%可信区间14.0%到37.6%)。50%或更大的减少部分每周发作频率达到44.6%的列弗组患者(45/101),19.6%(19/97)患者接受安慰剂(p = 0.0002)。7 (6.9%)LEV-treated患者控制发作在整个双盲治疗期,相比之下,一个病人(1.0%)接受安慰剂。 One or more adverse events were reported by 88.1% of LEV-treated patients and 91.8% of placebo patients. The most common treatment-emergent adverse events were somnolence, accidental injury, vomiting, anorexia, hostility, nervousness, rhinitis, cough, and pharyngitis. A similar number of patients in each group required a dose reduction or withdrew from the study as a result of an adverse event. Conclusion: Levetiracetam adjunctive therapy administered at 60 mg/kg/day is efficacious and well tolerated in children with treatment-resistant partial seizures.