TY -的T1 -吸收口头瓦解carbidopa-levodopa requires intact small bowel function JF - Neurology JO - Neurology SP - 1507 LP - 1507 DO - 10.1212/01.wnl.0000183286.92632.71 VL - 65 IS - 9 AU - Sanjay S. Iyer AU - John C. Morgan AU - Kapil D. Sethi Y1 - 2005/11/08 UR - //www.ez-admanager.com/content/65/9/1507.abstract N2 - Orally disintegrating tablet (ODT) technology is used in multiple pharmaceuticals.1 ODT carbidopa-levodopa (CD-LD) was introduced in 2004, and while this formulation is a more convenient dosing option for some patients, it still requires absorption in the proximal small intestine as does standard CD-LD. We report two patients with PD in whom ODT CD-LD was inappropriately used in the setting of paralytic ileus.Case 1.A 63-year-old woman with Parkinson disease (PD) for 8 years treated with standard CD-LD was admitted for cholecystectomy. Her postoperative course was complicated by paralytic ileus and encephalopathy, likely from sedative drugs. She was given ODT CD-LD during this period for her PD. We were consulted for worsening parkinsonism despite the patient taking an equivalent CD-LD preoperative dose in the form of ODT CD-LD. Our examination revealed global bradykinesia, marked cogwheel rigidity, and profound hypomimia. Once the ileus resolved, the patient resumed her preoperative dose of standard CD-LD and within 2 weeks she had returned to … ER -