RT期刊文章SR电子T1有氧训练对认知和大脑葡萄糖代谢的影响与轻度认知障碍(P3.084)科目摩根富林明神经学神经学乔FD Lippincott Williams &威尔金斯SP P3.084 VO 88 A1是16补充法比奥Henrique de波尔图球迷A1阿图尔Coutinho A1法比奥·杜兰A1安娜平托A1布鲁首页诺Gualano A1卡洛斯Buchpiguel A1里卡多Nitrini A1索尼娅Brucki年2017 UL //www.ez-admanager.com/content/88/16_Supplement/P3.084.abstract AB目的:评价有氧训练(AT)对认知的影响和区域大脑葡萄糖代谢(rBGM)在轻度认知障碍(MCI)。背景:尽管是一种很有前途的干预MCI,的影响在rBGM尚未完全理解。设计/方法:受试者进行了报项目24周中等强度。评估与ADAS-cog rBGM评价正前后进行干预。对照组(CG)在认知正常的老年人MCI的代谢差异比较之前和之后(在人口数据没有区别,除了MMSE (CG: 29 (1);MCI: 28 (1.6), p = 0.002)。使用相对最大有氧能力比较耗氧量最大摄氧量(毫升/公斤/分钟)。正数据分析与SPM8 voxel-by-voxel基础(阈值:未修正的p < 0.001,集群大小≥50像素点)。结果:六十五例中,平均年龄为69.2(5.5)年。比较采用配对t显示改善ADAS-cog(平均差:−2.4 (3.5),p < 0.001)和最大摄氧量的分数(平均差:1.4 (2.3)mL / kg /分钟,p < 0.001)。脑代谢分析显示两国减少rBGM的前颞波兰人,左额叶脑回,左前扣带皮质,海马、左额内侧回和双边尾状核。相比之下,有一个增加rBGM右侧楔前叶和左额下回。当比较rBGM与CG在MCI之前和之后,在左边有改善新陈代谢后楔前叶(之前:集群大小486压,p = 0.006; after AT: cluster size 100 voxels, p = 0.163).Conclusions: AT improved cognition and changed rBGM in areas related to cognition. Importantly, AT improved the metabolism in the precuneus cortex, an area associated with risk of conversion from MCI to Alzheimer’s disease.Disclosure: Dr. de Gobbi Porto has nothing to disclose. Dr. Coutinho has nothing to disclose. Dr. Duran has nothing to disclose. Dr. Pinto has nothing to disclose. Dr. Gualano has nothing to disclose. Dr. Buchpiguel has nothing to disclose. Dr. Nitrini has nothing to disclose. Dr. Brucki has nothing to disclose.

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