PT -期刊文章盟法比奥Henrique de米兰球迷波尔图盟-阿图尔Coutinho盟法比奥·杜兰AU - Ana平托盟布鲁诺Gualano AU -卡洛斯Buchpiguel AU -里卡多Nitrini AU -索尼娅Brucki TI -有氧训练对认知和大脑葡萄糖代谢的影响与轻度认知障碍(P3.084)科目DP - 2017年4月18日TA -神经病学PG - P3.084 VI - 88 IP - 16补充4099 - //www.ez-admanager.com/content/88/16_Supplement/P3.084.short 4100 - //www.ez-admanager.com/content/88/16_Supplement/P3.08首页4.full所以Neurology2017 4月18日;88 AB -目的:评估有氧训练(AT)对认知的影响和区域大脑葡萄糖代谢(rBGM)在轻度认知障碍(MCI)。背景:尽管是一种很有前途的干预MCI,的影响在rBGM尚未完全理解。设计/方法:受试者进行了报项目24周中等强度。评估与ADAS-cog rBGM评价正前后进行干预。对照组(CG)在认知正常的老年人MCI的代谢差异比较之前和之后(在人口数据没有区别,除了MMSE (CG: 29 (1);MCI: 28 (1.6), p = 0.002)。使用相对最大有氧能力比较耗氧量最大摄氧量(毫升/公斤/分钟)。正数据分析与SPM8 voxel-by-voxel基础(阈值:未修正的p & lt;0.001、集群大小≥50像素点)。结果:六十五例中,平均年龄为69.2(5.5)年。比较采用配对t显示改善ADAS-cog(平均差:−2.4 (3.5),p & lt; 0.001) and VO2 max scores (mean difference: 1.4 (2.3) mL/kg/min, p < 0.001). Brain metabolic analysis revealed a bilateral reduction of rBGM in both anterior temporal poles, left frontal gyrus, left anterior cingulate cortex, right hippocampus, left medial frontal gyrus and bilateral caudate nuclei. In contrast, there was an increase in rBGM in the right precuneus and left inferior frontal gyrus. When comparing rBGM in MCI before and after AT with CG, there was an improvement in the metabolism in the left precuneus after AT (before AT: cluster size 486 voxels, p = 0.006; after AT: cluster size 100 voxels, p = 0.163).Conclusions: AT improved cognition and changed rBGM in areas related to cognition. Importantly, AT improved the metabolism in the precuneus cortex, an area associated with risk of conversion from MCI to Alzheimer’s disease.Disclosure: Dr. de Gobbi Porto has nothing to disclose. Dr. Coutinho has nothing to disclose. Dr. Duran has nothing to disclose. Dr. Pinto has nothing to disclose. Dr. Gualano has nothing to disclose. Dr. Buchpiguel has nothing to disclose. Dr. Nitrini has nothing to disclose. Dr. Brucki has nothing to disclose.

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