TY - T1的血清自身抗体不区分从控制摩根富林明熊猫和图雷特综合症——神经学乔-神经病学SP - 1701 LP - 1707做wnl.0000183223.69946 10.1212/01.。首页f1六世- 65 - 11 AU -哈维美国歌手AU -约翰·j·洪盟达斯汀y Yoon AU -菲利普·n·威廉姆斯Y1 2005/12/13 UR - //www.ez-admanager.com/content/65/11/1701.abstract N2 -背首页景:谷蛋白机制提出了对于儿童自身免疫性神经精神障碍与链球菌感染有关(熊猫)和图雷特综合症(TS)。确认证据,部分是基于有争议的发现自身抗体的血清与这些疾病的孩子。目的:比较antineuronal抗体与TS受试者的概要文件和熊猫年龄组。方法:血清得到从48大熊猫,儿童和TS 46, 43个年龄组。血清自身抗体测定用ELISA和西方对多种抗原表位免疫印迹,包括人类死后的尾状核,前额叶皮层(大脑区域10)。免疫反应性也与商用α,γ-enolase醛缩酶C和丙酮酸激酶M1。几个化验后被重复preabsorption链球菌M6菌株的血清。结果:平均ELISA光密度读数组相似。免疫印迹分析显示复杂的染色模式没有任何组织地区差异基于乐队的数量,反应峰值在98分子量,60岁,45岁和40 kDa,或ScanPack面积(Biometra、哥廷根、德国)派生的峰值。 Immunoreactivity against four putative pathologic antigens did not differentiate the clinical groups. Repeat immunoblotting after serum preabsorption with streptococci showed no loss of reactivity. ELISA values exceeding a specified cutoff did not predict changes in binding to either brain epitopes or commercial antigens. Conclusions: Results do not support the hypothesis that PANDAS and Tourette syndrome are secondary to antineuronal antibodies. Longitudinal studies are required to determine whether autoantibodies correlate with fluctuations in clinical activity. ER -