TY -的T1 -黑质在阿尔茨海默病的病理与锥体束外的迹象JF -神经学乔-神经病学SP - 1397 LP - 1403 - 10.1212/01. wnl.0000158423.05224.7f六世64 -首页 8盟——j·m·伯恩斯盟——j·e·加尔文盟——c·m·罗伊AU - j·c·莫里斯盟d·w·麦基尔? Y1 - 2005/04/26 UR - //www.ez-admanager.com/content/64/8/1397.abstract N2 -背景:锥体束外的迹象(EPS)是常见的阿尔茨海默病(AD)和增加患病率随着广告的进步。neuropathologic衬底负责EPS的广告还有待充分的特点。方法:受试者的临床诊断证实了广告neuropathologic考试。EPS在生活记录的临床方法评估动作迟缓,齿轮刚度、地震,和帕金森步态。主题与EPS和先前的安定曝光被排除在外。28在EPS组和104例受试者没有每股收益。神经元损失,α-synuclein (ASYN)标记病理学,和黑质tau-labeled病理学是用半定量的测量技术,更高的分数代表病理增加负担。结果:存在nigral ASYN-labeled病理学是更为常见(50 vs 28.9%;p & lt;0.05)比那些没有EPS EPS组。 There was more nigral neuron loss in the EPS group (1.50 vs 1.11 in no-EPS group; p < 0.05). Tau-labeled burden was not different by group comparisons; however, EPS onset at later stages of dementia severity was associated with increased tau-labeled pathology (Kendall tau-B = 0.48, p < 0.01) and this association remained after controlling for dementia severity at death. Additionally, moderate to severe tau burden was more common in the subgroup with “pure AD” (definite AD without other neuropathology) with EPS (81.8%) than cases without EPS (49.0%; p < 0.05). Four subjects with EPS (14.3%) had little to no significant nigral pathologic changes. Conclusions: Clinically detected extrapyramidal signs (EPS) in Alzheimer disease (AD) are associated with substantia nigra pathology including α-synuclein aggregation, hyperphosphorylated tau accumulation, and neuron loss that may account for the increasing prevalence of EPS as AD progresses. In some cases, limited nigral pathology suggests extranigral factors in the clinical symptoms of EPS. ER -