RT期刊文章SR电子T1的自然历史时间变体额颞叶痴呆摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 1384 OP 1390做10.1212/01. wnl.0000首页158425.46019.5c VO 64 A1是8 W。w·斯利A1。m·鲍尔A1 b l·米勒A1 m . l . Gorno-Tempini A1 j·h·克雷默A1 m·维纳A1 h·j·罗森年2005 UL //www.ez-admanager.com/content/64/8/138首页4.abstract AB背景:颞额颞叶痴呆的变体(tvFTD)功能不对称的前颞/杏仁核变性以及腹内侧前额岛,inferoposterior时间参与。左颞萎缩与语义知识的损失,而行为症状主导右颞变体。摘要目的:探讨第一症状和随后的时机左和右tvFTD患者症状。方法:26例tvFTD患者确认。6有右>左颞叶萎缩(右颞叶变种[RTLV]),并与六左可比>右颞叶萎缩(左颞叶变种[LTLV])。综述了临床记录年表来生成个性化的症状。结果:所有的患者,首先症状涉及语义(LTLV 4/6, 1/6 RTLV)、行为(4/6 RTLV LTLV 1/6),或两者兼而有之(1 LTLV, 1 RTLV)。语义损失开始命名障碍、种种困难和重复的演讲,而早期行为综合症表现为情感距离,易怒,破坏生理驱动(睡眠、食欲、性欲)。 After an average of 3 years, patients developed whichever of the two initial syndromes—semantic or behavioral—that they lacked at onset. A third stage, 5 to 7 years from onset, saw the emergence of disinhibition, compulsions, impaired face recognition, altered food preference, and weight gain. Compulsions in LTLV were directed toward visual, nonverbal stimuli, whereas patients with RTLV were drawn to games with words and symbols. Conclusions: The temporal variant of frontotemporal dementia follows a characteristic cognitive and behavioral progression that suggests early spread from one anterior temporal lobe to the other. Later symptoms implicate ventromedial frontal, insular, and inferoposterior temporal regions, but their precise anatomic correlates await confirmation.