作者@article {Seeley1384 = {W。w·斯利和a . m . Bauer和b·l·米勒和m . l . Gorno-Tempini j·h·克雷默和m·维纳·h·j·罗森},title ={}颞变体额颞叶痴呆的自然历史,体积={64}={8},页面= {1384 - 1390}= {2005},doi = {10.1212/01. wnl.0000158425.46019.5c},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={背景:颞额颞叶痴呆的变体(tvFTD)功能不对称的前颞/杏仁核变性以及腹内侧前额岛,和inferoposterior时间参与。首页左颞萎缩与语义知识的损失,而行为症状主导右颞变体。摘要目的:探讨第一症状和随后的时机左和右tvFTD患者症状。方法:26例tvFTD患者确认。6有右\ >左颞叶萎缩(右颞叶变种[RTLV]),并与六左可比\ >右颞叶萎缩(左颞叶变种[LTLV])。综述了临床记录年表来生成个性化的症状。结果:所有的患者,首先症状涉及语义(LTLV 4/6, 1/6 RTLV)、行为(4/6 RTLV LTLV 1/6),或两者兼而有之(1 LTLV, 1 RTLV)。语义损失开始命名障碍、种种困难和重复的演讲,而早期行为综合症表现为情感距离,易怒,破坏生理驱动(睡眠、食欲、性欲)。平均3年后,患者开发任何两个初始症状的语义或行为{\ textemdash} {\ textemdash},他们缺乏在发病。 A third stage, 5 to 7 years from onset, saw the emergence of disinhibition, compulsions, impaired face recognition, altered food preference, and weight gain. Compulsions in LTLV were directed toward visual, nonverbal stimuli, whereas patients with RTLV were drawn to games with words and symbols. Conclusions: The temporal variant of frontotemporal dementia follows a characteristic cognitive and behavioral progression that suggests early spread from one anterior temporal lobe to the other. Later symptoms implicate ventromedial frontal, insular, and inferoposterior temporal regions, but their precise anatomic correlates await confirmation.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/64/8/1384}, eprint = {//www.ez-admanager.com/content/64/8/1384.full.pdf}, journal = {Neurology} }