TY -的T1(<一口> 99 < /一口> Tc) TRODAT-1 SPECT成像与气味识别早期帕金森病JF -神经学乔-神经病学SP - 1716 LP - 1720 - 10.1212/01. wnl.0000161874.52302.5d首页六世- 64是a - 10盟Siderowf盟——a·纽伯格盟k . l .周盟- m·劳埃德盟- a . Colcher盟- h . i Hurtig AU - m·b·斯特恩盟r . l . Doty AU - p·d·Mozley盟n越冬AU - j·e·杜达盟- d·温特劳布非盟- p . j . Moberg Y1 - 2005/05/24 UR - //www.ez-admanager.com/content/64/10/1716.abstract N2 -背景:体内成像的多巴胺转运体(99矿渣mtc) TRODAT-1(卓达)和嗅觉测试都被建议作为帕金森病(PD)的潜在生物标志物。摘要目的:评价卓达SPECT成像的关系,气味识别技能和早期PD患者的运动功能。Methods: Twenty-four patients with a clinical diagnosis of early-stage PD (mean Hoehn & Yahr stage = 1.4) underwent TRODAT imaging, Unified PD Rating Scale (UPDRS) ratings of motor function, and administration of the University of Pennsylvania Smell Identification Test (UPSIT). Brain images were obtained using a standardized processing protocol and specific uptake ratios for striatal regions of interest were calculated. Partial correlations between the imaging indices, disease duration, UPSIT scores, and UPDRS motor scores were then calculated. Results: UPSIT scores were correlated with TRODAT uptake in the striatum as a whole (r = 0.66, p = 0.001). The putamen showed the strongest correlation with the UPSIT (r = 0.74; p < 0.001). The correlation between dopamine transporter density in the caudate and UPSIT was moderate (r = 0.36, p = 0.11), but was not significant. Conclusions: Olfactory function is highly correlated with dopamine transporter imaging abnormalities in early Parkinson disease (PD). Further studies are warranted to determine whether changes over time in these two measures are also correlated in early PD. ER -