TY - T1的初始用抗癫痫药物治疗癫痫JF -神经学乔-神经病学SP - S30 LP - S39做- 10.1212 / WNL.63.10_su首页ppl_4。S30六世- 63 - 10 5 4 AU -拉曼Sankar Y1 - 2004/11/23 UR - //www.ez-admanager.com/首页content/63/10_suppl_4/S30.abstract N2 -选择一个初始抗癫痫药物(AED)治疗癫痫在婴儿期,童年,青少年应该明确后综合征病人的癫痫疾病的诊断。第一个AED的失败的常见原因是错误的诊断。新一代aed的可用性扩大了可用的代理的选择对于大多数症状与类似的功效。疗效数据基于类I或II证据没有童年的许多症状,因此选择必须是基于最好的数据。同样重要的是评估的相对毒性和耐受性aed做出选择。尤为重要的是,要感谢特异性器官毒性。此外,使用aed的童年需要了解神经行为的影响。重要的癫痫儿童神经精神疾病包括注意缺陷/多动障碍、自闭症谱系障碍,抑郁和焦虑,和思想障碍。这些问题可以通过特定的aed加剧或改善。 The effect of AEDs on body weight, insulin sensitivity, lipid profile, and bone health is becoming better appreciated. Newer AEDs may offer significant advantages in this regard. Co-morbid migraine in children with epilepsy may benefit from some AEDs. There remains a continuing need for the development of newer AEDs that are targeted for the developing brain to improve the efficacy and tolerability of treatment in childhood seizure disorders. ER -