作者@article {SankarS30 ={喇曼Sankar}, title ={最初用抗癫痫药物治疗癫痫},体积={63},数量={10 5 4},页面= {S30 S39},年= {2004},doi = {10.1212 / WNL.63.10_suppl_4。出版商S30} = {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={选择最初的抗癫痫药物(AED)治疗癫痫在婴儿期,童年和青春期理想情况下应该明首页确后综合征的诊断病人的{\ textquoteright}癫痫症。第一个AED的失败的常见原因是错误的诊断。新一代aed的可用性扩大了可用的代理的选择对于大多数症状与类似的功效。疗效数据基于类I或II证据没有童年的许多症状,因此选择必须是基于最好的数据。同样重要的是评估的相对毒性和耐受性aed做出选择。尤为重要的是,要感谢特异性器官毒性。此外,使用aed的童年需要了解神经行为的影响。重要的癫痫儿童神经精神疾病包括注意缺陷/多动障碍、自闭症谱系障碍,抑郁和焦虑,和思想障碍。这些问题可以通过特定的aed加剧或改善。 The effect of AEDs on body weight, insulin sensitivity, lipid profile, and bone health is becoming better appreciated. Newer AEDs may offer significant advantages in this regard. Co-morbid migraine in children with epilepsy may benefit from some AEDs. There remains a continuing need for the development of newer AEDs that are targeted for the developing brain to improve the efficacy and tolerability of treatment in childhood seizure disorders.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/63/10_suppl_4/S30}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }