TY - T1的手术局部皮质发育不良JF -神经学乔-神经病学SP - S30 LP - S34做wnl.0000首页114508.31261 10.1212/01.。E6六世- 62 - 6,85盟-威廉·e·宾格曼Y1 - 2004/03/23 UR - //www.ez-admanager.com/content/62/6首页_suppl_3/S30.abstract N2 -局灶性皮质发育不良(FCD)经常与医学有关难治性癫痫。1 - 3⇓⇓强大的神经影像技术的出现彻底改变了这个困难的识别和管理的障碍。尽管意识,增加手术的历史收益率没有希望的结果比其他公认癫痫症状。2 - 6⇓⇓⇓⇓不存在公认的分类方案。大脑皮层发育不良、畸形、神经元迁移障碍和皮质发育不全所有适当的条款在正确的设置。FCD,被泰勒等al.1 1971年,意味着无序与异常的大脑皮层神经元的病理诊断(气球细胞)。在皮质神经元迁移障碍是指一个扰动发展产生在他们注定的皮质神经元的迁移位置。其他条款不太具体,意味着随时发生异常的脑皮质发育分化过程中,移民,和成熟的大脑皮层。读者被称为皮质发展几个优秀的评论更详细的信息。3、7、8⇓⇓分级基于组织病理学和神经影像可能的皮质畸形临床相关的预测epileptogenicity和手术结果。6、9⇓此外,个别畸形可能有不同的脑电图签名,最终需要不同的手术方法。这可能会围绕着气球细胞的存在与否。 Clinical investigations studying mechanisms of epileptogenicity in different subtypes of dysplasia are ongoing. The true incidence of FCD remains unclear. Before the availability of modern neuroimaging techniques, diagnosis depended solely on histopathology from surgical specimens of patients with epilepsy.10–12⇓⇓ A recent autopsy series of 7,374 brains found a 1.7% incidence of FCD in normal brains.13 The incidence was significantly higher (46.5%) in patients with epilepsy. Other centers report a 2 to 36% incidence in surgically treated epilepsy series.4,14⇓ In pediatric patients with intractable epilepsy, the incidence was 25% … ER -