PT -期刊文章AU - f . g . Gilliam盟——a·j·费斯勒盟——g·贝克盟诉Vahle AU - j·卡特盟h . Attarian TI -系统筛选允许减少抗癫痫药物副作用援助- 10.1212 / WNL.62.1.23 DP - 2004年1月13日TA -神经病学PG - 23 - 27 VI - 62 IP - 1 4099 - //www.ez-admanager.com/content/62/1/23.short 4100 - http://n.neurolo首页gy.org/content/62/1/23.full Neurology2004 1月13;62 AB -目的:确定系统的有效性筛选简要19-item自我报告工具,不良事件概要(AEP),减少抗癫痫药物(aed)的不利影响,提高主观健康状况。方法:作者进行了前瞻性随机试验比较AEP的使用和没有AEP的常规治疗。六十二患者AEP分数≥45岁为一组连续的200成年人癫痫。结果:平均百分比AEP改善患者组的分数更大的临床医生收到了AEP较常规治疗组(25% vs 5%;p & lt;0.01)。意味着生活质量的变化在癫痫库存(QOLIE) -89总分没有不同团体,但对整个样本QOLIE - 89变化是更大的改善对病人有15 AEP得分比那些有0 - 15点的改善或恶化评分(24和12和3;方差分析,p & lt;0.008)。 More patients in the AEP group had a >15-point improvement in QOLIE-89 score (p < 0.03). Use of the AEP was associated with a 2.8-fold increase (95% CI, 1.7 to 4.8) in AED modifications. No difference in seizure rates was observed. Conclusions: Systematic screening for antiepileptic drug side effects may increase identification of toxicity and guide medication changes to reduce adverse effects and possibly improve subjective health status.