TY -摩根富林明的T1 - clinical-DWI不匹配神经学乔-神经病学SP - 21首页87 LP - 2192做wnl.0000130570.41127 10.1212/01.。EA六世- 62 a - 12盟Davalos AU - m·布兰科盟盟美国佩德拉泽- r . Leira AU - m·卡斯特罗盟- j . m . Pumar AU - y席尔瓦AU - j .小威盟- j·卡斯蒂略Y1 - 2004/06/22 UR - //www.ez-admanager.com/content/62/12/2187.abstract N2 -目的:评估的有首页用性急性临床表现的严重程度之间的不匹配和diffusion-weighted成像(驾车)病变在预测早期中风的结果和梗塞体积。方法:一百六十六例半球缺血性中风& lt; 12小时的持续时间进行了研究。美国国立卫生研究院卒中量表(署)评分和醉酒驾车病变的体积测量在住院和72±12小时。梗塞体积测量在t2加权或fluid-attenuated反转恢复图像在30天。早期神经功能恶化(结束)被定义为增加≥4分两署评估。38个患者接受静脉溶栓或abciximab。Clinical-DWI不匹配(CDM)被定义为署得分≥8和缺血性成交量驾车≤25毫升的承认。清洁发展机制的调整影响,在72小时驾车病变扩大,梗塞在30天的增长是通过逻辑回归分析评估和广义线性模型。结果:清洁发展机制被发现在87名患者(52.4%)。 Patients with CDM had a higher risk of END than patients without CDM because NIHSS < 8 (odds ratio [OR], 9.0; 95% CI,1.9 to 42) or DWI lesion > 25 mL (OR, 2.0; 95% CI, 0.8 to 4.9). CDM was associated with an increase of 46 to 68 mL in the mean volume of DWI lesion enlargement and infarct growth in comparison with non-CDM. All the effects were even greater and significant in patients not treated with reperfusion therapies. Conclusions: Acute stroke patients with an NIHSS score of ≥8 and DWI volume of ≤25 mL have a higher probability of infarct growth and early neurologic deterioration. The new concept of CDM may identify patients with tissue at risk of infarction for thrombolytic or neuroprotective drugs. ER -