TY - T1的定量测定患者的疼痛感的帕金森病JF -神经学乔-神经病学SP - 2171 LP - 2175 - 10.1212/01. wnl.0000130455.38550.9d六世62 首页- 12非盟- r . Djaldetti AU - a Shifrin盟- z Rogowski AU - e . Sprecher盟- e . Melamed盟- d Yarnitsky Y1 - 2004/06/22 UR - //www.ez-admanager.com/content/62/12/2171.abstract N2 -背景:疼痛是常见的帕金森病(PD)患者,可以先于疾病的诊断。实验研究和临床证据表明基底神经节和多巴胺能通路参与中枢疼痛处理。目的:定量评估和比较疼痛知觉在单方面的PD患者和患者没有痛苦和响应的波动。方法:36 PD患者(平均年龄61.8±11.2岁),主要是单方面的疾病,患者15响应波动(平均年龄65.3±10.4岁),和28的同龄健康受试者参与了这项研究。主观疼痛评估使用视觉模拟量表和冯·弗雷细丝触觉阈值和接触变温器温热感觉(WS)和热痛阈值(hpt)。结果:触觉和WS阈值之间没有差别在患者组和对照组患者之间也没有。HPT低在PD患者经历了痛苦(n = 21)与那些没有(42.6±3.0°C vs 45.6±2.8°C;p & lt;0.01)和那些经历过疼痛更影响(41.4±2.6°C vs 43.7±3.3°C;p & lt; 0.0001). In patients with fluctuations there were no side differences in WS and HPT or between “on” and “off” periods. Conclusion: Endogenous pain in patients with Parkinson disease is accompanied by increased sensitivity to some painful stimuli, suggesting that basal ganglia abnormality also involves pain encoding. ER -