@article {BielekovaP4.395作者= {Bibiana Bielekova和彼得•科莎公司克里斯托弗·巴伯和米卡小森和Makoto Tanigawa天下吴邦国委员长和代约翰逊和罗纳德·Herbst和王曰和基思谭和马克Grenwood}, title ={分子诊断多发性硬化及其进步的阶段(P4.395)},体积={88}={16}补充数量,elocation-id = {P4.395} ={2017},出版商= {Wolters Kluwer健康,公司代表美国神经病学学会},文摘={目的:确定在多发性硬化症(MS)的一个例子如果脑脊液(CSF)签名的复杂的神经系统疾病允许他们的可靠的分化条件,有重叠的临床或成像特性或有共同的病理生理学。首页背景:分子生物标志物诊断的援助,允许在廉价的二期试验和筛选治疗指南选择的患者在大多数内科学科复方用药方案。相比之下,没有验证测量的生理状态,或功能障碍(s)不同的细胞在中枢神经系统(CNS)。因此,治疗慢性神经系统疾病患者通常有一个单一的疾病修饰治疗没有理解特定的驱动程序的残疾。设计/方法:使用慢不管修改DNA寡核苷酸适配子(SOMAscan)试验,我们测量1128的脑脊液蛋白225未经处理的对象从六个诊断类别(25健康的捐赠者,40人分别从复发缓和女士(名RRMS),小学和secondary-progressive女士,非炎症和其他神经系统炎症性疾病)发现队列。技术和生物复制的生物标记辅助选择最高的信噪比,这作为一个输入统计学习方法,随机森林。模型的性能进行了测试在一个独立的验证群从相同的6 85例诊断类别。结果:分子诊断试验的女士使用17个变量来区分女士从所有其他条件验证接受者操作特征曲线下面积(AUC)为0.95。这个测试是由免疫学生物标志物。主,secondary-progressive女士在生理上无法区分,定量可比名RRMS囊内的炎症。从进步分子测试区分名RRMS女士验证AUC = 0.90是基于27变量相关oligodendroglial和神经损伤。Conclusions: The identified molecular taxonomy maybe helpful in diagnostically challenging cases and provides opportunities for biomarker-supported drug development in MS. Our data are applicable to other CNS diseases.Disclosure: Dr. Bielekova received patent royalty payments from National Institutes of Health. Dr. Kosa has nothing to disclose. Dr. Barbour has nothing to disclose. Dr. Komori has nothing to disclose. Dr. Tanigawa has nothing to disclose. Dr. Wu, PhD. has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Herbst has received personal compensation for activities with Medimmune as an employee. Dr. Herbst holds stock and/or stock options in Medimmune, which sponsored research in which Dr. Herbst was involved as an investigator. Dr. Herbst holds stock and/or stock options in Medimmune. Dr. Wang has received personal compensation for activities with Medimmune as an employee. Dr. Wang holds stock and/or stock options in Medimmune. Dr. Tan has received personal compensation for activities with MedImmune as an employee. Dr. Tan holds stock and/or stock options in MedImmune. Dr. Grenwood has nothing to disclose.}, issn = {0028-3878}, URL = {//www.ez-admanager.com/content/88/16_Supplement/P4.395}, eprint = {//www.ez-admanager.com/content}, journal = {Neurology} }