TY - T1的直立性低血压交感神经支配的帕金森病JF -神经学乔-神经病学SP - 1247 LP - 1255 - 10.1212 / WNL.58.8.1247六世- 58 - 8 AU首页 - d·s·戈尔茨坦AU - c . s .福尔摩斯AU - r . Dendi AU - s . r . Bruce盟S.-T。李Y1 - 2002/04/23 UR - http://n.ne首页urology.org/content/58/8/1247.abstract N2 -背景:PD患者经常有自主失败的迹象或症状,包括直立性低血压。心脏交感神经支配PD中经常发生,但这被认为独立自主的失败发生。方法:41 PD患者(18、23没有直立性低血压)和16的同龄健康志愿者进行PET扫描可视化交感神经支配后注射6 - [18 f] fluorodopamine。Beat-to-beat血压反应并发操作被用来识别同情neurocirculatory失败和血浆去甲肾上腺素,表明整体交感神经支配。结果:所有患者PD和直立性低血压异常血压反应并发操作间隔和侧心室心肌6 - [18 f] fluorodopamine-derived放射性浓度在2 SD低于正常的意思。相比之下,只有6的23个患者无直立性低血压并发异常反应(p & lt;0.0001与直立性低血压)患者相比,只有11广泛地减少6 - [18 f] fluorodopamine-derived放射性的左心室心肌(p = 0.0004)。剩下的12个病人无直立性低血压,7有局部心肌放射性下降。仰卧的血浆去甲肾上腺素是较低的患者比那些没有直立性低血压(1.40±0.15 vs 2.32±0.26 nmol / L, p = 0.005)。 6-[18F]fluorodopamine-derived radioactivity was less not only in the myocardium but also in the thyroid and renal cortex of patients with PD than in healthy control subjects. Conclusions: In PD, orthostatic hypotension reflects sympathetic neurocirculatory failure from generalized sympathetic denervation. ER -