% 0期刊文章% P . J .凯利%一个J . Rosand % % j.p.基斯特勒公司诉e . Shih % s对峙% A . Plomaritoglou % k·l·富里% T同型半胱氨酸,MTHFR 677 c→T多态性与缺血性中风的风险2002% % B的荟萃分析结果% D R 10.1212 / WNL.59.4.529 % J神经病学% P 529 - 536 V % 59% 4% N X背景:数据冲突的有关缺血性中风的风险与hyperhomocyst (e) inemia (hyper-Hcy)和常见的多态首页性基因编码5 10-methylenetetrahydrofolate还原酶(MTHFR 677 c→T),易诱发hyper-Hcy体内。方法:寻找MEDLINE,科学引文索引,会议记录的摘要显示相关文章。接触定义如下:1)hyper-Hcy患病率;2)主题之间的绝对差异意味着Hcy浓度有无缺血性中风;和3)MTHFR TT基因型的频率。结果被定义为缺血性中风有或没有神经影像。入选标准是回顾性和前瞻性研究报道优势比(或)或风险比率(人力资源)或算术平均值Hcy水平。排除标准缺乏或人力资源,结果定义为颈动脉粥样硬化或内中膜增厚,中风病人18岁以下,除英语之外的其他语言的学习。统计分析之间的异质性和集中风险的估计进行了使用占据软件(占据公司,大学城,TX)。结果:16个研究(1487中风和2554 nonstroke病例),池意味着缺血性患者Hcy水平斯托克是2.32μmol / L(95%可信区间,1.6 - 3.04; p < 0.001) greater than that in those without ischemic stroke. Among 14 included studies (1,769 stroke and 7,400 nonstroke cases), the pooled OR estimate of ischemic stroke associated with hyper-Hcy was 1.79 (95% CI, 1.61 to 2.0; p < 0.001). Among 19 included studies (2,788 stroke and 3,962 nonstroke cases), the OR associated with the TT genotype was 1.23 (95% CI, 0.96 to 1.58; p = 0.1). Conclusion: These data support an association between mild-to-moderate hyper-Hcy and ischemic stoke. The MTHFR TT genotype may have a small influence in determining susceptibility to ischemic stoke. %U //www.ez-admanager.com/content/neurology/59/4/529.full.pdf