TY -的T1 -左旋多巴输液对电动机的影响活化反应帕金森病JF -神经学乔-神经病学SP - 220 LP - 226 - 10.1212 / WNL.59.2.220费金六世- 59 - 2非盟- a首页 . AU - m . f . Ghilardi AU - m .福田AU - m . j .正常的非盟- v . Dhawan盟a·巴恩斯AU - c·p·Ghez AU - d Eidelberg Y1 - 2002/07/23 UR - //www.ez-admanager.com/content/59/2/220.abstract N2 -背景:临床改善与左旋多巴治疗帕金森病与特定区域脑葡萄糖代谢的变化。然而,未知如何这些影响静息状态与治疗的改变发生在运动的大脑功能。在这项研究中,作者用宠物来评估左旋多巴在电动机活化反应的影响,确定这些变化如何与在线录音的运动速度和精度。方法:七个右撇子PD患者进行扫描H215O /宠物在执行一种可预测的节奏达到运动序列,观察相同的屏幕显示和音调。宠物研究中“上”和“关闭”状态以恒定速率分别滴定左旋多巴注入;运动动控制在治疗条件。结果:左旋多巴改善“关闭”状态UPDRS运动评级(34%;p & lt;0.006)和运动时间(18%;p = 0.001)。 Spatial errors worsened during levodopa infusion (24%; p = 0.02). Concurrent regional cerebral blood flow (rCBF) recordings revealed significant enhancement of motor activation responses in the posterior putamen bilaterally (p < 0.001), left ventral thalamus (p < 0.002), and pons (p < 0.005). Movement time improvement with treatment correlated with rCBF increases in the left globus pallidus and left ventral thalamus (p < 0.01). By contrast, the increase in spatial errors correlated with rCBF increases in the cerebellar vermis (p < 0.01). Conclusion: These results suggest that levodopa infusion may improve aspects of motor performance while worsening others. Different components of the motor cortico-striato-pallido-thalamo-cortical loop and related pathways may underlie motor improvement and adverse motoric effects of levodopa therapy for PD. ER -