TY -的T1 Aβ-deposition阶段的人类大脑及其相关性的发展广告JF -神经学乔-神经病学SP - 1791 LP - 1800 - 10.1212 / WNL.58.12.1791六世- 58 - 1首页2 AU -迪特马尔r .需要盟Udo摩擦AU -马里奥Orantes盟海科Braak Y1 - 2002/06/25 UR - //www.ez-admanager.com/content/58/12/1791.abstract N2 -背景:淀粉样β蛋白的沉积(Aβ)是一个广告的病理特点。区域的内侧颞叶(MTL)参与Aβ-deposition等级。目的:明确是否有层次的参与整个大脑区域,是否有差异的扩张Aβ-pathology之间临床证明广告案例和nondemented AD-related病理情况下,作者研究了47个大脑从精神错乱和nondemented AD-related患者病理覆盖所有阶段的β-amyloidosis MTL (AβMTL阶段)和四个控制大脑没有任何AD-related病理学。方法:检测到Aβ存款Campbell-Switzer银的使用技术和免疫组织化学的部分覆盖所有大脑区域和脑干核。它分析了频率不同的地区表现出Aβ存款。结果:前五个阶段的进化β-amyloidosis Aβ存款只大脑皮层中被发现。第二阶段的特点是额外allocortical大脑区域的参与。在第三阶段,间脑的核,纹状体和基底前脑胆碱能核的展览Aβ存款。另外几个脑干核成为参与第四阶段。第五阶段,最后,特点是小脑Aβ-deposition。17临床证明广告案例展览Aβ-phases 3、4或5。 The nine nondemented cases with AD-related Aβ pathology show Aβ-phases 1, 2, or 3.Conclusions: Aβ-deposition in the entire brain follows a distinct sequence in which the regions are hierarchically involved. Aβ-deposition, thereby, expands anterogradely into regions that receive neuronal projections from regions already exhibiting Aβ. There are also indications that clinically proven AD cases with full-blown β-amyloidosis may be preceded in early stages by nondemented cases exhibiting AD-related Aβ pathology. ER -