RT期刊文章SR电子T1双边人类胎儿纹状体移植在亨廷顿氏舞蹈症摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 687 OP 695做的是10.1212 / WNL.58.5.687首页 VO 58 A1 r·a·豪泽A1 s Furtado A1 c·r·西米洛A1 h . Delgado A1 s为A1 s . Schwartz A1 d·斯科特A1通用Nauert A1大肠Soety A1 V。Sossi A1 d·A·霍尔特A1 p . r . Sanberg A1。j . Stoessl A1 t·弗里曼年2002 UL http://n.neurology.首页org/content/58/5/687.abstract AB背景:纹状体移植细胞已经被证明是为了生存,成长,建立传入和传出连接,提高行为迹象亨廷顿氏舞蹈症(HD)的动物模型。目的:评估可行性和安全性并提供初步信息的有效性两国在高清的人类胎儿纹状体移植。方法:七个症状患者基因确认高清双边立体定向移植后2到8个胎儿striata每侧两个过程。组织切割侧侧脑室的一半隆起的捐助者postconception 8到9周。受试者接受环孢霉素为6个月。结果:三个主题开发硬膜下出血(sdh)和两个必需手术引流。一个主题18个月手术后死于心律失常可能继发于严重的动脉粥样硬化性心脏病。尸检表明清楚地划定移植的典型的发展中纹状体形态、与host-derived多巴胺能纤维延伸到移植和免疫排斥反应的证据。 Other adverse events were generally mild and transient. Mean Unified HD Rating Scale (UHDRS) motor scores were 32.9 ± 6.2 at baseline and 29.7 ± 7.5 12 months after surgery (p = 0.24). Post-hoc analysis, excluding one subject who experienced cognitive and motor deterioration after the development of symptomatic bilateral SDHs, found that UHDRS motor scores were 33.8 ± 6.2 at baseline and 27.5 ± 5.2 at 12 months (p = 0.03). Conclusions: Transplantation of human fetal striatal cells is feasible and survival of transplanted cells was demonstrated. Patients with moderately advanced HD are at risk for SDH after transplantation surgery.

map