TY - T1的撤军后头痛的临床特征过度使用药物和其他头痛药物JF -神经学乔-神经病学SP - 1694 LP - 1698 - 10.1212 / WNL.57.9.1694六世- 57 - 9 AU - z Katsarava首页 AU - g . Fritsche AU - m . Muessig盟H.C. Diener AU - v Limmroth Y1 - 2001/11/13 UR - //www.ez-admanager.com/content/57/9/1694.abstract N2 -背景:完全退出头痛药物是治疗的首选药物过度引起头痛。停止滥用头痛的药物,然而,结果发展的撤军头痛,常伴有恶心、呕吐,和睡眠障碍。方法:在95名患者的前瞻性研究,作者调查了撤军后头痛的持续时间和严重程度过度使用各种头痛的药物,包括单一和组合止痛剂,麦角和药物。所有患者接受标准住院戒断治疗14天。结果:撤军头痛持续时间短于病人过度使用药物(4.1天)比病人过度使用麦角(6.7天)或止痛剂(9.5天;p < 0.002). The mean headache intensity on the first day of withdrawal did not differ between the groups (p = 0.821). By day 14, however, it was lower in patients overusing triptans (0.08) than in patients overusing ergots (0.4) or analgesics (0.9; p < 0.005). Rescue medication was requested less by patients undergoing triptan withdrawal (0.25 requests) than by patients undergoing ergot withdrawal (1.25) or analgesic withdrawal (1.85; p < 0.05). Similar to findings in the entire patient population, withdrawal headache was shorter and less severe in migraineurs overusing triptans than in those overusing ergots or analgesics. Because only patients with migraine, but no patient with tension-type headache, overused triptans, withdrawal headache was shorter in the group of patients with migraine alone (6.7 days versus 9.6 days for patients with tension-type headache and 8.5 days for patients with combination headache, p < 0.02). Conclusion: The duration and severity of withdrawal clearly depend on the type of overused headache drug only. ER -