RT期刊文章SR电子T1的准确性临床标准广告Honolulu-Asia老化研究,以人群为基础的研究摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP 226 OP 234 10.1212 / WNL.57.2.226 VO 57是2 首页A1 h . Petrovitch A1 L.R.白色A1 G.W.罗斯A1南卡罗来纳州Steinhorn A1 C.Y.李A1 K.H.正树A1 D.G.戴维斯A1 j·纳尔逊A1 j . Hardman A1 J.D.抑制A1 P.L.布兰切特A1第50 Launer A1 K。矢野A1得到Markesbery年2001 UL http://n.neurology.首页org/content/57/2/226.abstract AB目的:确定诊断准确性广告以人群为基础的日裔美国人的研究。广告是神经病理证实超过80%的病例在主要的转诊中心(主要是白种人);然而,诊断准确性的信息在以人群为基础的研究和不同民族的研究是有限的。方法:共有3734人参加了Honolulu-Asia老化研究1991年到1993年痴呆考试考试在1994年到1996年和2603年。诊断是根据公布的标准。神经病理学家蒙蔽神经原纤维缠结临床数据量化(非功能性测试)和神经炎的斑块(NP)。结果:220年的解剖,临床评估显示68年认知正常,73中间,与老年痴呆症和79:20个广告,27血管性痴呆,公元19 +其他,其他13个痴呆。20例中纯广告,最大皮层非功能性测试密度的中位数是6.9 /平方毫米和皮层NP密度为8.0 /平方毫米。相应的密度对其他组< 3.0 /平方毫米。 Using established neuropathologic criteria, 25% (5/20) of clinical AD cases had enough NP to meet definite AD criteria, whereas 65% (13/20) had sufficient NP to meet neuropathologic definite or probable AD criteria. Among nine AD cases with moderately severe dementia, only two (22%) had NP densities great enough to meet definite neuropathologic criteria, whereas seven (78%) met neuropathologic criteria for probable AD. Conclusions: Neuropathologic confirmation and NP density among decedents with clinical AD in this population-based study were lower than reported by referral centers and similar to reports from two other community studies. Ethnic differences in propensity for amyloid deposition as well as differences in clinical severity and representativeness of cases might contribute to these findings.